Transient receptor potential cation channel subfamily M member 5 (TRPM5) Recombinant Protein | TRPM5 recombinant protein

Recombinant Human Transient receptor potential cation channel subfamily M member 5 (TRPM5) , partial

• Gene Names: TRPM5; MTR1; LTRPC5
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transient receptor potential cation channel subfamily M member 5 (TRPM5); Recombinant Human Transient receptor potential cation channel subfamily M member 5 (TRPM5); partial; TRPM5 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 872

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 11225266
• NCBI GeneID: 29850
• NCBI Accession #: NP_055370.1
• NCBI GenBank Nucleotide #: NM_014555.3
• UniProt Accession #: Q9NZQ8; Q52LU2; Q9NY34; A6NHS0
• Molecular Weight: 97,738 Da
• NCBI Official Full Name: transient receptor potential cation channel subfamily M member 5
• NCBI Official Synonym Full Names: transient receptor potential cation channel subfamily M member 5
• NCBI Official Symbol: TRPM5
• NCBI Official Synonym Symbols: MTR1; LTRPC5
• NCBI Protein Information: transient receptor potential cation channel subfamily M member 5
• UniProt Protein Name: Transient receptor potential cation channel subfamily M member 5
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: TRPM5
• UniProt Synonym Gene Names: LTrpC-5; LTrpC5

NCBI Description

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

Uniprot Description

Voltage-modulated Ca2+-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na+, K+ and Cs+ ions equally well. Activated directly by increases in intracellular Ca2+, but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca2+. Also activated by a fast intracellular Ca2+ increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.