E3 ubiquitin-protein ligase TRIM37 (Trim37) Recombinant Protein | Trim37 recombinant protein

Recombinant Mouse E3 ubiquitin-protein ligase TRIM37 (Trim37) , partial

• Gene Names: Trim37; MUL; TEF3; AI848587; AU043018; mKIAA0898; 1110032A10Rik; 2810004E07Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: E3 ubiquitin-protein ligase TRIM37 (Trim37); Recombinant Mouse E3 ubiquitin-protein ligase TRIM37 (Trim37); partial; Trim37 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 961

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Trim37 recombinant protein

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and
or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 37574064
• NCBI GeneID: 68729
• NCBI Accession #: NP_932104.1
• NCBI GenBank Nucleotide #: NM_197987.2
• UniProt Accession #: Q6PCX9; Q5SX31; Q8CHC5
• Molecular Weight: 107,660 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase TRIM37
• NCBI Official Synonym Full Names: tripartite motif-containing 37
• NCBI Official Symbol: Trim37
• NCBI Official Synonym Symbols: MUL; TEF3; AI848587; AU043018; mKIAA0898; 1110032A10Rik; 2810004E07Rik
• NCBI Protein Information: E3 ubiquitin-protein ligase TRIM37
• UniProt Protein Name: E3 ubiquitin-protein ligase TRIM37
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: Trim37

NCBI Description

The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]

Uniprot Description

E3 ubiquitin-protein ligase required to prevent centriole reduplication (). Probably acts by ubiquitinating positive regulators of centriole reduplication (). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042).