Human Triggering receptor expressed on myeloid cells 2 ELISA Kit | TREM2 elisa kit

Human Triggering receptor expressed on myeloid cells 2 ELISA Kit

Cat. Num. AAA2880663

• Gene Names: TREM2; TREM-2; Trem2a; Trem2b; Trem2c
• Reactivity: Human
• Synonyms: Triggering receptor expressed on myeloid cells 2; Human Triggering receptor expressed on myeloid cells 2 ELISA Kit; TREM-2; Triggering receptor expressed on monocytes 2; TREM2; TREM2 elisa kit

• Reactivity: Human
• Sequence Length: 219

• Samples: Serum, Plasma, Tissue Homogenates, Cell Culture Supernates Or Other Biological Fluids.
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for TREM2 elisa kit

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 425876764
• NCBI GeneID: 54209
• NCBI Accession #: NP_001258750.1
• NCBI GenBank Nucleotide #: NM_001271821.1
• UniProt Accession #: Q9NZC2; Q8N5H8; Q8WYN6
• Molecular Weight: 24,669 Da
• NCBI Official Full Name: triggering receptor expressed on myeloid cells 2 isoform 2
• NCBI Official Synonym Full Names: triggering receptor expressed on myeloid cells 2
• NCBI Official Symbol: TREM2
• NCBI Official Synonym Symbols: TREM-2; Trem2a; Trem2b; Trem2c
• NCBI Protein Information: triggering receptor expressed on myeloid cells 2
• UniProt Protein Name: Triggering receptor expressed on myeloid cells 2
• Protein Family: Triggering receptor expressed on myeloid cells
• UniProt Gene Name: TREM2
• UniProt Synonym Gene Names: TREM-2
• UniProt Entry Name: TREM2_HUMAN

NCBI Description

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Uniprot Description

TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: extracellular region; integral to membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function: lipopolysaccharide binding; peptidoglycan binding; receptor activity

Biological Process: axon guidance; detection of lipopolysaccharide; detection of peptidoglycan; humoral immune response; innate immune response; phagocytosis, engulfment; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; regulation of immune response

Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy