TNF receptor-associated factor 3 (Traf3) Recombinant Protein | Traf3 recombinant protein

Recombinant Mouse TNF receptor-associated factor 3 (Traf3)

Cat. Num. AAA1481819

• Gene Names: Traf3; amn; LAP1; CAP-1; CRAF1; T-BAM; CD40bp; AI528849
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: TNF receptor-associated factor 3 (Traf3); Recombinant Mouse TNF receptor-associated factor 3 (Traf3); Traf3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-567, Full length protein
• Sequence: MESSKKMDAAGTLQPNPPLKLQPDRGAGSVLVPEQGGYKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQESIIKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP
• Sequence Length: 567

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Traf3 recombinant protein

This protein is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

NCBI and Uniprot Product Information

• NCBI GI #: 114842405
• NCBI GeneID: 22031
• NCBI Accession #: NP_035762.2
• NCBI GenBank Nucleotide #: NM_011632.3
• UniProt Accession #: Q60803; Q62380; B2RPW3
• Molecular Weight: 64,294 Da
• NCBI Official Full Name: TNF receptor-associated factor 3 isoform a
• NCBI Official Synonym Full Names: TNF receptor-associated factor 3
• NCBI Official Symbol: Traf3
• NCBI Official Synonym Symbols: amn; LAP1; CAP-1; CRAF1; T-BAM; CD40bp; AI528849
• NCBI Protein Information: TNF receptor-associated factor 3
• UniProt Protein Name: TNF receptor-associated factor 3
• Protein Family: TNF receptor-associated factor
• UniProt Gene Name: Traf3
• UniProt Synonym Gene Names: Craf1; Trafamn; CRAF1

Uniprot Description

Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.