Human two pore segment channel 1 ELISA Kit | TPCN1 elisa kit
Human Two pore calcium channel protein 1, TPCN1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
Uniprot Description
TPCN1: one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane. Highest expression found in the heart and kidney, and lowest expression found in the spleen. Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. Two alternatively spliced human isoforms have been described.
Protein type: Transporter; Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel
Chromosomal Location of Human Ortholog: 12q24.13
Cellular Component: lysosomal membrane; plasma membrane; integral to membrane; endosome membrane
Molecular Function: voltage-gated calcium channel activity; identical protein binding; protein binding
Biological Process: calcium ion transport; transmembrane transport
Research Articles on TPCN1
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Product Notes
The Human TPCN1 tpcn1 (Catalog #AAA9337143) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337143 ELISA Kit recognizes Human TPCN1. It is sometimes possible for the material contained within the vial of "two pore segment channel 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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