Mouse TRAF2 and NCK interacting kinase ELISA Kit | TNIK elisa kit
Mouse TRAF2 and NCK-interacting protein kinase, TNIK ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TNIK: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1. Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; STE group; STE20 family; MSN subfamily
Cellular Component: nucleoplasm; recycling endosome; cytoskeleton; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; nucleus; endosome
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: nervous system development; microvillus biogenesis; Wnt receptor signaling pathway; protein amino acid autophosphorylation; regulation of dendrite morphogenesis; actin cytoskeleton reorganization; response to stress; cytoskeleton organization and biogenesis; positive regulation of protein amino acid phosphorylation; phosphorylation; protein amino acid phosphorylation; activation of JNKK activity
Research Articles on TNIK
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Product Notes
The Mouse TNIK tnik (Catalog #AAA9327669) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327669 ELISA Kit recognizes Mouse TNIK. It is sometimes possible for the material contained within the vial of "TRAF2 and NCK interacting kinase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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