TL1A recombinant protein
TL1A, (soluble) (mouse), (recombinant)
Applications
ELISA, Flow Cytometry, Functional Assay
Purity
>=95% (SDS-PAGE)
Synonyms
TL1A; (soluble) (mouse); (recombinant); TL1A recombinant protein
Host
HEK293 cells
Purity/Purification
>=95% (SDS-PAGE)
Form/Format
Lyophilized. Contains PBS
Concentration
0.1mg/ml after reconstitution (varies by lot)
Applicable Applications for TL1A recombinant protein
ELISA (EIA), Flow Cytometry (FC/FACS)
Source Note
The extracellular domain of mouse TL1A (aa 94-252) is fused at the N-terminus to a linker peptide (8 aa) and a DYKDDDDK-tag
Endotoxin
<0.1EU/ug purified protein (LAL test)
Reconstitution
Reconstitute with 100ul sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein
Preparation and Storage
Stable for at least 6 months after receipt when stored at -20 degree C
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 degree C
Shipping: Shipped on Blue Ice
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 degree C
Shipping: Shipped on Blue Ice
Related Product Information for TL1A recombinant protein
TL1A (TNFSF15), a ligand belonging to the tumor necrosis factor (TNF) family, is expressed predominantly by endothelial cells and monocytes. TL1a is upregulated by the proinflammatory cytokines TNF and IL-1 and also by immune complexes (IC). TL1 functions in T cell costimulation and Th1 polarization. On activated T cells, TL1A functions specifically via its surface-bound receptor DR3, (a member of the death-domain containing TNF receptor family) to promote cell survival and secretion of proinflammatory cytokines. The secreted decoy receptor 3 (DcR3), a soluble protein of the tumor necrosis factor receptor (TNFR) superfamily blocks the action of TL1A. TL1A can be released to circulate as a homotrimeric soluble form. Activation of DR3 by TL1A induced the formation of a signaling complex containing TRADD, TRAF2, and RIP and activated the NF-kappaB and the ERK, JNK, and p38 mitogen-activated protein kinase pathways. The TL1A/DR3 pathway plays an important role in Th1-mediated intestinal diseases, such as Crohn's disease.
Product Categories/Family for TL1A recombinant protein
NCBI and Uniprot Product Information
Uniprot Description
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis (). Promotes splenocyte alloactivation.
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Product Notes
The TL1A tnfsf15 (Catalog #AAA566244) is a Recombinant Protein produced from HEK293 cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TL1A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the TL1A tnfsf15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TL1A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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