Rabbit anti-Human TNFSF15 Polyclonal Antibody | anti-Tnfsf15 antibody

TNFSF15, NT (Tumor Necrosis Factor Ligand Superfamily Member 15, TNF Ligand-related Molecule 1, Vascular Endothelial Cell Growth Inhibitor, TL1, VEGI)

Cat. Num. AAA6006883

• Gene Names: Tnfsf15; Tl1; Tl1a; Vegi
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Purified; Purified by Ion Exchange chromatography.
• Synonyms: TNFSF15; Polyclonal Antibody; NT (Tumor Necrosis Factor Ligand Superfamily Member 15; TNF Ligand-related Molecule 1; Vascular Endothelial Cell Growth Inhibitor; TL1; VEGI); Anti -TNFSF15; anti-Tnfsf15 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human TL1A. Species sequence homology: mouse and rat
• Purity/Purification: Purified; Purified by Ion Exchange chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-Tnfsf15 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot, Immunohistochemistry.; Dilution: Western Blot: 0.5-1ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to 14aa from near the N-terminal of human TL1A (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Placenta (formalin-fixed, paraffin-embedded) stained with TNFSF15 antibody at 5ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Western Blot (WB)

(Western blot analysis of TL1A in PC-3 cell lysates with TL1A antibody at (A) 0.5, (B) 1, and (C) 2 µg/ml.)

Related Product Information for anti-Tnfsf15 antibody

TL1A is also known as tumor necrosis factor ligand superfamily member 15 (TNFSF15). TL1A acts as a co-stimulator of IFN-gamma secretion through binding to DR3 (death domain receptor 3 or TRAMP) and may play an important role in Th1-mediated diseases such as Crohn's disease. In cells expressing DR3, TL1A induces NF-kappa-B activation and apoptosis. Decoy receptor 3 (DcR3) is also a receptor for TL1A. DcR3 can apparently neutralise the effect of TL1A, by inhibiting the TL1A-DR3 interaction, thereby inhibiting apoptosis. TL1A is specifically expressed on endothelial cells and is detected on monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Product Categories/Family for anti-Tnfsf15 antibody

Antibodies; Abs to Growth Factors; Cytokines

NCBI and Uniprot Product Information

• NCBI GI #: 238776819
• NCBI GeneID: 326623
• NCBI Accession #: NP_796345.3
• NCBI GenBank Nucleotide #: NM_177371.3
• UniProt Accession #: Q5UBV8; Q8K3Y8
• Molecular Weight: 27,723 Da
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 15
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 15
• NCBI Official Symbol: Tnfsf15
• NCBI Official Synonym Symbols: Tl1; Tl1a; Vegi
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; vascular endothelial growth inhibitor; vascular endothelial cell growth inhibitor; bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15)
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 15
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: Tnfsf15
• UniProt Synonym Gene Names: Tl1; Vegi
• UniProt Entry Name: TNF15_MOUSE

Uniprot Description

TNFSF15: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Apoptosis; Membrane protein, integral

Cellular Component: extracellular space; membrane; plasma membrane; extracellular region; integral to membrane

Molecular Function: death receptor binding; cytokine activity; tumor necrosis factor receptor binding

Biological Process: caspase activation; apoptosis; cytokine metabolic process; activation of NF-kappaB-inducing kinase; immune response; signal transduction; positive regulation of cytokine secretion