BCMA (CD269) Recombinant Protein | BCMA recombinant protein

Human BCMA (CD269) Recombinant

Cat. Num. AAA553161

• Purity: >95%, as determined by SDS-PAGE and HPLC
• Synonyms: BCMA (CD269); Human BCMA (CD269) Recombinant; cd269; bcma; TNFRSF17; BCMA recombinant protein

• Host: E Coli
• Purity/Purification: >95%, as determined by SDS-PAGE and HPLC
• Form/Format: Recombinant BCMA was lyophilized from a 0.2 um filtered 30% acetonitrile, 0.1% TFA solution pH 7.5.

• Host Note: Optimized DNA sequence encoding Human BCMA extracellular domain was expressed in Escherichia Coli.
• Endotoxin: Endotoxin content was assayed using a LAL gel clot method.; Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Molecular Weight Note: Recombinant BCMA is a disulfide-linked monomer protein consisting of 54 amino acid residue subunits, and migrates as an approximately 6kDa protein under non-reducing and reducing conditions in SDS-PAGE.
• Biological Activity: The ED(50) was not determined.
• Preparation and Storage: The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.; Upon reconstitution, this product can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. ; ; Avoid repeated freeze/thaw cycles.

Related Product Information for BCMA recombinant protein

BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes.The N-terminal part of both mouse and human proteins contains a conserved six- cysteine motif. BLyS binds to three receptors of the TNF receptor family (B cell maturation antigen BCMA, TACI, and BAFF-R), all of which are expressed by mature B cells.

Product Categories/Family for BCMA recombinant protein

Cytokines

References

• autoantibody-producing rp105– b cells, from patients with systemic lupus erythematosus, showed more preferential expression of BCMA compared with baff-r than normal subjects .Rheumatology, Jan 2010; 10.1093/rheumatology/kep437.
• adipocytes as immune cells: differential expression of tweak, baff, and april and their receptors (fn14, baff-r, taci, and BCMA) at different stages of normal and pathological adipose tissue development .J. Immunol., Nov 2009; 183: 5948 - 5956.
• activation of b-cell maturation antigen (BCMA) on human multiple myeloma cells by a proliferation-inducing ligand (april) promotes myeloma cell function in the bone marrow microenvironment. .Blood (ASH Annual Meeting Abstracts), Nov 2007; 110: 1503.
• the rgel/blys fusion toxin specifically targets malignant b cells expressing the blys receptors baff-r, taci, and BCMA .Mol. Cancer Ther., Feb 2007; 6: 460 - 470.
• hodgkin lymphoma cells express taci and BCMA receptors and generate survival and proliferation signals in response to baff and april .Blood, Jan 2007; 109: 729 - 739.