TNF-IP 1 Blocking Peptide | TNF-IP1 blocking peptide

TNF-IP 1 (S122) Peptide

Cat. Num. AAA3002685

• Applications: Blocking
• Purity: Synthetic peptide TNF-IP 1 (S122). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: TNF-IP 1; TNF-IP 1 (S122) Peptide; alpha-induced protein 1; BACD2; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; endothelial; hBACURD2; Protein B12; tnfaip1; Tumor necrosis factor alpha induced protein 1 (endothelial); Tumor necrosis factor alpha induced protein 1; Tumor necrosis factor; TNF-IP1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002684 TNF-IP 1 (S122) pAb.
• Purity/Purification: Synthetic peptide TNF-IP 1 (S122). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 316

• Applicable Applications for TNF-IP1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for TNF-IP1 blocking peptide

TNFalpha-IP 1 (tumor necrosis factor, alpha-induced protein 1, endothelial), also known as B12, B61, EDP1 or TNFAIP1, is a BTB/POZ domain-containing protein that belongs to the KCTD10/KCTD13/TNFAIP1 family. TNFalpha-IP 1 contains one BTB/POZ motif, which is known to mediate homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. The expression of TNFalpha-IP 1 can be induced by IL-6 and by TNFalpha in the umbilical vein of endothelial cells. TNFalpha-IP 1 may be involved in DNA repair, DNA synthesis, cell apoptosis and human diseases. TNFalpha-IP 1 is suggested to play a role in the process of cancer and in the innate immunity against the Hepatitis B virus.

NCBI and Uniprot Product Information

• NCBI GI #: 10863937
• NCBI Accession #: NP_066960.1
• NCBI GenBank Nucleotide #: NP_066960.1
• UniProt Accession #: Q13829
• NCBI Official Full Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
• UniProt Protein Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
• UniProt Gene Name: TNFAIP1
• UniProt Synonym Gene Names: BACURD2; EDP1; hBACURD2
• UniProt Entry Name: BACD2_HUMAN

Uniprot Description

TNFAIP1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Belongs to the BACURD family.

Protein type: DNA replication; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17q22-q23

Cellular Component: cytoplasm; nucleolus; endosome

Molecular Function: protein domain specific binding; protein binding; ubiquitin-protein ligase activity; GTP-Rho binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; cell migration; embryonic development; negative regulation of Rho protein signal transduction; apoptosis; stress fiber formation; protein ubiquitination; immune response; DNA replication; protein homooligomerization; positive regulation of DNA replication