Toll Like Receptor 2 Recombinant Protein | mTLR2 recombinant protein
Recombinant Mouse Toll Like Receptor 2
Solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
Introduction: TLR2 belongs to the Toll-like receptor (TLR) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) which are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
NCBI and Uniprot Product Information
Uniprot Description
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response () (PubMed:15690042). May also promote apoptosis in response to lipoproteins (). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (PubMed:17486091). Acts as the major receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR1 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Recombinant MPT83 from M.tuberculosis stimulates secretion of cytokines (TNF-alpha, IL-6 and IL-12p40) by mouse macrophage cell lines in a TLR2-dependent fashion, which leads to increased host innate immunity responses against the bacterium (PubMed:22174456). Lung macrophages which express low levels of TLR2 respond poorly to stimulation by M.tuberculosis LpqH (PubMed:19362712). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (PubMed:27220037).
Research Articles on mTLR2
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Product Notes
The mTLR2 tlr2 (Catalog #AAA147219) is a Recombinant Protein produced from Sf9, Baculovirus cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ADL QESLSCD ASGVCDGRSR SFTSIPSGLT AAMKSLDLSF NKITYIGHGD LRACANLQVL MLKSSRINTI EGDAFYSLGS LEHLDLSDNH LSSLSSSWFG PLSSLKYLNL MGNPYQTLGV TSLFPNLTNL QTLRIGNVET FSEIRRIDFA GLTSLNELEI KALSLRNYQS QSLKSIRDIH HLTLHLSESA FLLEIFADIL SSVRYLELRD TNLARFQFSP LPVDEVSSPM KKLAFRGSVL TDESFNELLK LLRYILELSE VEFDDCTLNG LGDFNPSESD VVSELGKVET VTIRRLHIPQ FYLFYDLSTV YSLLEKVKRI TVENSKVFLV PCSFSQHLKS LEFLDLSENL MVEEYLKNSA CKGAWPSLQT LVLSQNHLRS MQKTGEILLT LKNLTSLDIS RNTFHPMPDS CQWPEKMRFL NLSSTGIRVV KTCIPQTLEV LDVSNNNLDS FSLFLPRLQE LYISRNKLKT LPDASLFPVL LVMKIRENAV STFSKDQLGS FPKLETLEAG DNHFVCSCEL LSFTMETPAL AQILVDWPDS YLCDSPPRLH GHRLQDARPS VLECHQLEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH. It is sometimes possible for the material contained within the vial of "Toll Like Receptor 2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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