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Thrombospondin 1 Recombinant Protein | THBS1 recombinant protein
Recombinant Thrombospondin 1 (THBS1)
Source: Prokaryotic expression
MGHHHHHHSG SEF- GVQRRSRLCN NPTPQFGGKD CVGDVTENQV CNKQDCPIDG CLSNPCFAGA KCTSYPDGSW KCGACPPGYS GNGIQCKDVD ECKEVPDACF NHNGEHRCKN TDPGYNCLPC PPRFTGSQPF GRGVEHAMAN KQVCKPRNPC TDGTHDCNKN AKCNYLGHYS
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
SDS-Page
SDS-Page
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
Uniprot Description
THBS1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Belongs to the thrombospondin family.
Protein type: Motility/polarity/chemotaxis; Inhibitor
Chromosomal Location of Human Ortholog: 15q15
Cellular Component: extracellular matrix; extracellular space; cell surface; sarcoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum; fibrinogen complex; extracellular region; external side of plasma membrane; secretory granule
Molecular Function: heparin binding; identical protein binding; laminin binding; calcium ion binding; integrin binding; proteoglycan binding; protein binding; fibroblast growth factor binding; transforming growth factor beta binding; phosphatidylserine binding; fibronectin binding; low-density lipoprotein binding; glycoprotein binding
Biological Process: extracellular matrix organization and biogenesis; positive regulation of blood coagulation; positive regulation of translation; activation of MAPK activity; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of caspase activity; behavioral response to pain; response to magnesium ion; negative regulation of fibrinolysis; platelet degranulation; response to glucose stimulus; cell cycle arrest; cell adhesion; positive regulation of macrophage activation; response to drug; protein amino acid O-linked glycosylation; positive regulation of transforming growth factor-beta1 production; platelet activation; positive regulation of tumor necrosis factor biosynthetic process; negative regulation of interleukin-12 production; chronic inflammatory response; cell migration; positive regulation of chemotaxis; positive regulation of blood vessel endothelial cell migration; negative regulation of focal adhesion formation; positive regulation of transforming growth factor beta receptor signaling pathway; engulfment of apoptotic cell; response to testosterone stimulus; post-translational protein modification; negative regulation of blood vessel endothelial cell migration; negative regulation of cell-matrix adhesion; response to unfolded protein; positive regulation of protein kinase B signaling cascade; negative regulation of angiogenesis; positive regulation of angiogenesis; cellular protein metabolic process; response to mechanical stimulus; negative regulation of dendritic cell antigen processing and presentation; negative regulation of endothelial cell proliferation; response to hypoxia; immune response; regulation of cGMP metabolic process; sprouting angiogenesis; peptide cross-linking; blood coagulation; response to calcium ion; response to progesterone stimulus; positive regulation of phosphorylation; negative regulation of apoptosis; positive regulation of cell migration
Research Articles on THBS1
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Product Notes
The THBS1 thbs1 (Catalog #AAA2030116) is a Recombinant Protein produced from Host: E Coli Source: Prokaryotic expression and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Thrombospondin 1 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the THBS1 thbs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below.MGHHHHHHS G SEF- GVQRRSRLCN NPTPQFGGKD CVGDVTENQV CNKQDCPIDG CLSNPCFAGA KCTSYPDGSW KCGACPPGYS GNGIQCKDVD ECKEVPDACF NHNGEHRCKN TDPGYNCLPC PPRFTGSQPF GRGVEHAMAN KQVCKPRNPC TDGTHDCNKN AKCNYLGHYS
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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