Stathmin 1 Recombinant Protein | STMN1 recombinant protein

Stathmin 1 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121875

• Gene Names: STMN1; Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
• Purity: >85% as determined by SDS-PAGE
• Synonyms: Stathmin 1; Stathmin 1 Protein; Human; Recombinant (His Tag); Human STMN1/Stathmin 1 Protein (His Tag); C1orf215 Protein; Lag Protein; LAP18 Protein; OP18 Protein; PP17 Protein; PP19 Protein; PR22 Protein; SMN Protein; stathmin 1; STMN1 recombinant protein

• Host: E Coli
• Purity/Purification: >85% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asp149

• Species: Human
• Predicted N Terminal: His
• Tag: N-His
• Protein Construction: A DNA sequence encoding the human STMN1 (NP_005554.1)(Met1-Asp149) was expressed with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

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Related Product Information for STMN1 recombinant protein

Background: Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and could be a novel therapeutic target in metastatic GC. STMN1 expression might serve as a biomarker for determining patient atypical meningioma prognosis. Stathmin1 (STMN1) is a cytosolic protein involved in microtubule dynamics through inhibition of tubulin polymerization and promotion of microtubule depolymerization, which has been implicated in carcinogenesis and aggressive behavior in multiple epithelial malignancies. Stathmin 1 (STMN1) suppression was reported to reduce cellular viability and migration potential. STMN1 may be a promising candidate for targeted therapies in PDAC.

NCBI and Uniprot Product Information

• NCBI GI #: 5031851
• NCBI GeneID: 3925
• NCBI Accession #: NP_005554.1
• NCBI GenBank Nucleotide #: NM_005563.3
• UniProt Accession #: P16949; A2A2D1; B2R4E7; B7Z8N4; D3DPJ5
• Molecular Weight: 19,824 Da
• NCBI Official Full Name: stathmin isoform a
• NCBI Official Synonym Full Names: stathmin 1
• NCBI Official Symbol: STMN1
• NCBI Official Synonym Symbols: Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
• NCBI Protein Information: stathmin; prosolin; metablastin; oncoprotein 18; phosphoprotein 19; phosphoprotein p19; stathmin 1/oncoprotein 18; transmembrane protein C1orf215; leukemia-associated phosphoprotein p18
• UniProt Protein Name: Stathmin
• Protein Family: Stathmin
• UniProt Gene Name: STMN1
• UniProt Synonym Gene Names: C1orf215; LAP18; OP18; Op18; pp19
• UniProt Entry Name: STMN1_HUMAN

NCBI Description

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Uniprot Description

STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: microtubule; neuron projection; membrane; cytoplasm; intracellular; cytosol

Molecular Function: tubulin binding; signal transducer activity

Biological Process: mitotic spindle organization and biogenesis; axonogenesis; negative regulation of microtubule polymerization; response to virus; microtubule depolymerization; positive regulation of cell motility; brain development; signal transduction; neurite development; regulation of cytoskeleton organization and biogenesis