Typical Testing Data/Standard Curve (for reference only)
Mouse TGF-beta receptor type-2 ELISA Kit | Tgfbr2 elisa kit
Mouse TGF-beta receptor type-2 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to TGFR-2. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated polyclonal antibody preparation specific for TGFR-2 and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain TGFR-2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The concentration of TGFR-2 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
NCBI and Uniprot Product Information
Uniprot Description
TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.
Protein type: Kinase, protein; Protein kinase, TKL; Oncoprotein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; TKL group; STKR family; Type2 subfamily
Cellular Component: caveola; cell surface; cytoplasm; cytosol; external side of plasma membrane; integral to membrane; integral to plasma membrane; lipid raft; membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; glycosaminoglycan binding; kinase activity; metal ion binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type II; transmembrane receptor protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; apoptosis; brain development; cartilage development; cell differentiation; common-partner SMAD protein phosphorylation; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; gastrulation; heart development; in utero embryonic development; lens development in camera-type eye; lung development; myeloid dendritic cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of cell proliferation; Notch signaling pathway; organ morphogenesis; palate development; patterning of blood vessels; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of B cell tolerance induction; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of smooth muscle cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; receptor-mediated endocytosis; regulation of cell proliferation; regulation of gene expression; regulation of growth; response to drug; smoothened signaling pathway; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; vasculogenesis
Research Articles on Tgfbr2
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Product Notes
The Mouse Tgfbr2 tgfbr2 (Catalog #AAA2885129) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2885129 ELISA Kit recognizes Mouse Tgfbr2. It is sometimes possible for the material contained within the vial of "TGF-beta receptor type-2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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