Typical Testing Data/Standard Curve (for reference only)
Rat Protransforming growth factor alpha ELISA Kit | Tgfa elisa kit
Rat Protransforming growth factor alpha ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
acts as an EGF receptor ligand; inhibits apoptosis that results from epithelial detachment from the extracellular matrix [RGD, Feb 2006]
Uniprot Description
TGFalpha: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell cycle regulation; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis
Cellular Component: basolateral plasma membrane; cell surface; cytoplasmic vesicle; extracellular space; integral to plasma membrane; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: epidermal growth factor receptor binding; glycoprotein binding; growth factor activity
Biological Process: activation of MAPK activity; angiogenesis; epidermal growth factor receptor signaling pathway; negative regulation of apoptosis; negative regulation of cellular process; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor activity; positive regulation of epithelial cell proliferation; positive regulation of mitosis; response to drug; wound healing
Research Articles on Tgfa
Similar Products
Product Notes
The Rat Tgfa tgfa (Catalog #AAA2881232) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2881232 ELISA Kit recognizes Rat Tgfa. It is sometimes possible for the material contained within the vial of "Protransforming growth factor alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
