TIE-2 Fc Chimera Recombinant Protein | mTIE-2 Fc recombinant protein
Recombinant Mouse TIE-2 Fc Chimera
Sterile Filtered White lyophilized (freeze-dried) powder.
Introduction: TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1122 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 726 residue extracellular domain and a 353 residue cytoplasmic domain. Two ligands, angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2), which bind TIE-2 with high-affinity have been identified. Ang2 has been reported to act as an antagonist for Ang1. Mice engineered to overexpress Ang2 or to lack Ang1 or Tie-1 display similar angiogenic defects.
NCBI and Uniprot Product Information
Uniprot Description
TIE2: a receptor tyrosine kinase of the Tie family. Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian endothelial cell lineage marker. Appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; TK group; Tie family
Cellular Component: cell surface; microvillus; integral to plasma membrane; basolateral plasma membrane; extracellular region; integral to membrane; actin filament; intercellular junction; lipid raft; cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; plasma membrane; basal plasma membrane; stress fiber; cell junction
Molecular Function: transferase activity; protein binding; growth factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; receptor activity; ATP binding; protein kinase activity
Biological Process: positive regulation of cell adhesion; peptidyl-tyrosine phosphorylation; heart development; protein amino acid autophosphorylation; cell-matrix adhesion; positive regulation of cytokine secretion during immune response; regulation of cell migration; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; cell-cell adhesion; positive regulation of focal adhesion formation; hemopoiesis; angiogenesis; vasculogenesis; regulation of endothelial cell proliferation; Tie receptor signaling pathway; response to retinoic acid; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase activity; positive regulation of peptidyl-serine phosphorylation; regulation of angiogenesis; protein oligomerization; positive regulation of phosphoinositide 3-kinase cascade; patterning of blood vessels; positive regulation of protein kinase B signaling cascade; negative regulation of angiogenesis; positive regulation of angiogenesis; positive regulation of protein import into nucleus; response to estrogen stimulus; endothelial cell proliferation; sprouting angiogenesis; positive regulation of protein amino acid phosphorylation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
Research Articles on mTIE-2 Fc
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Product Notes
The mTIE-2 Fc tek (Catalog #AAA142795) is a Recombinant Protein produced from Chinese Hamster Ovarian Cells (CHO) and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TIE-2 Fc Chimera, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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