Mouse thymine-DNA glycosylase ELISA Kit | TDG elisa kit
Mouse G/T mismatch-specific thymine DNA glycosylase, TDG ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TDG: In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar- phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. Belongs to the TDG/mug DNA glycosylase family.
Protein type: EC 3.2.2.29; Nuclear receptor co-regulator; DNA repair, damage; Hydrolase
Cellular Component: nucleoplasm; PML body; plasma membrane; nucleus
Molecular Function: protein domain specific binding; hydrolase activity, hydrolyzing N-glycosyl compounds; protein homodimerization activity; structure-specific DNA binding; hydrolase activity; DNA N-glycosylase activity; hydrolase activity, acting on glycosyl bonds; transcription factor binding; mismatched DNA binding; protein binding; SUMO binding; protein kinase C binding; double-stranded DNA binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity
Biological Process: transcription from RNA polymerase II promoter; embryonic development; mismatch repair; regulation of transcription, DNA-dependent; transcription, DNA-dependent; metabolic process; base-excision repair; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; DNA repair; negative regulation of protein binding; regulation of gene expression, epigenetic; response to DNA damage stimulus
Research Articles on TDG
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Product Notes
The Mouse TDG tdg (Catalog #AAA9316165) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9316165 ELISA Kit recognizes Mouse TDG. It is sometimes possible for the material contained within the vial of "thymine-DNA glycosylase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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