Uncharacterized protein C8orf4 homolog Recombinant Protein | Tcim recombinant protein
Recombinant Mouse Uncharacterized protein C8orf4 homolog
NCBI and Uniprot Product Information
Uniprot Description
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (PubMed:24937306). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling ().
Research Articles on Tcim
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Product Notes
The Tcim tcim (Catalog #AAA1311818) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-106, full length protein. The amino acid sequence is listed below: MKAKPSHQAT SMSSSLRVSP SIHGYHFDTA ARKKAVGNIF ENIDQESLQR LFRNSGDKKA EERAKIIFAI DQDLEEKTRA LMALKKRTKD KLLQFLKLRK YSIKVH. It is sometimes possible for the material contained within the vial of "Uncharacterized protein C8orf4 homolog, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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