Trichohyalin Blocking Peptide | TCHH blocking peptide

Trichohyalin Blocking Peptide

Cat. Num. AAA9622095

• Gene Names: TCHH; THH; THL; TRHY; UHS3
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: Trichohyalin; Trichohyalin Blocking Peptide; 220K trichohyalin granular protein; Hair follicle protein AHF; MGC157889; MGC157890; RP11-107M16.3; TCHH; THH; THL; TRHY_HUMAN; Trichohyalin granular protein; TCHH blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for TCHH blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TCHH blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 148746195
• NCBI GeneID: 7062
• NCBI Accession #: NP_009044.2
• NCBI GenBank Nucleotide #: NP_009044.2
• UniProt Accession #: Q07283; Q5VUI3
• Molecular Weight: 253,925 Da
• NCBI Official Full Name: trichohyalin
• NCBI Official Synonym Full Names: trichohyalin
• NCBI Official Symbol: TCHH
• NCBI Official Synonym Symbols: THH; THL; TRHY; UHS3
• NCBI Protein Information: trichohyalin
• UniProt Protein Name: Trichohyalin
• Protein Family: Trichohyalin
• UniProt Gene Name: TCHH
• UniProt Synonym Gene Names: THH; THL; TRHY

NCBI Description

The protein encoded by this gene forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. The encoded protein also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene are a cause of uncombable hair syndrome. [provided by RefSeq, Feb 2017]

Uniprot Description

Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.