Tubulin-specific chaperone E (TBCE) Recombinant Protein | TBCE recombinant protein

Recombinant Human Tubulin-specific chaperone E (TBCE)

Cat. Num. AAA1339251

• Gene Names: TBCE; HRD; KCS; KCS1; pac2; PEAMO
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Tubulin-specific chaperone E (TBCE); Recombinant Human Tubulin-specific chaperone E (TBCE); TBCE recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-527, Full length protein
• Sequence: SDTLTADVIGRRVEVNGEHATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGSFIRPNKVNFGTDFLTAIKNRYVLEDGPEEDRKEQIVTIGNKPVETIGFDSIMKQQSQLSKLQEVSLRNCAVSCAGEKGGVAEACPNIRKVDLSKNLLSSWDEVIHIADQLRHLEVLNVSENKLKFPSGSVLTGTLSVLKVLVLNQTGITWAEVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSNQLIDENQLYLIAHLPRLEQLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWSFFNELEKLPSLRALSCLRNPLTKEDKEAETARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPEKNRLSEEFLTAHPRYQFLCLKYGAPEDWELKTQQPLMLKNQLLTLKIKYPHQLDQKVLEKQLPGSMTIQKVKGLLSRLLKVPVSDLLLSYESPKKPGREIELENDLKSLQFYSVENGDCLLVRW
• Sequence Length: 526

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for TBCE recombinant protein

Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D
beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 118442828
• NCBI GeneID: 6905
• NCBI Accession #: NP_001072983.1
• NCBI GenBank Nucleotide #: NM_001079515.2
• UniProt Accession #: Q15813; A8K8C2; B7Z3P1
• Molecular Weight: 64,852 Da
• NCBI Official Full Name: tubulin-specific chaperone E isoform a
• NCBI Official Synonym Full Names: tubulin folding cofactor E
• NCBI Official Symbol: TBCE
• NCBI Official Synonym Symbols: HRD; KCS; KCS1; pac2; PEAMO
• NCBI Protein Information: tubulin-specific chaperone E
• UniProt Protein Name: Tubulin-specific chaperone E
• Protein Family: Tubulin-specific chaperone
• UniProt Gene Name: TBCE

NCBI Description

Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.