Human tyrosine aminotransferase ELISA Kit | TAT elisa kit

Human tyrosine aminotransferase, TAT ELISA Kit

Reactivity

Human

Synonyms

tyrosine aminotransferase; Human tyrosine aminotransferase; TAT ELISA Kit; Human tyrosine aminotransferase (TAT) ELISA kit; cytosolic; TAT elisa kit

Ordering
Cat. Num. AAA9325158 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Human

Preparation and Storage

Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

NCBI GI #

4507369

NCBI GeneID

6898

NCBI Accession #

NP_000344.1

NCBI GenBank Nucleotide #

NM_000353.2

UniProt Accession #

P17735; B2R8I1; D3DWS2

Molecular Weight

50,399 Da

NCBI Official Full Name

tyrosine aminotransferase

NCBI Official Synonym Full Names

tyrosine aminotransferase

NCBI Official Symbol

TAT

NCBI Protein Information

tyrosine aminotransferase; tyrosine aminotransferase, cytosolic; L-tyrosine:2-oxoglutarate aminotransferase

UniProt Protein Name

Tyrosine aminotransferase

Protein Family

Tyrosine aminotransferase

UniProt Gene Name

TAT

UniProt Synonym Gene Names

TAT

UniProt Entry Name

ATTY_HUMAN

NCBI Description

This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]

Uniprot Description

TAT: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. Defects in TAT are the cause of tyrosinemia type 2 (TYRO2); also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 2.6.1.5; Transferase; Mitochondrial

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: mitochondrion; cytosol

Molecular Function: amino acid binding; tyrosine transaminase activity; pyridoxal phosphate binding

Biological Process: response to mercury ion; L-phenylalanine catabolic process; glutamate metabolic process; tyrosine catabolic process; response to glucocorticoid stimulus; biosynthetic process; response to oxidative stress; 2-oxoglutarate metabolic process

Disease: Tyrosinemia, Type Ii

Research Articles on TAT

1. Two known mutations and one novel mutation was found in the TAT gene of Tunesian Richner-Hanhart syndrome patients. The geographical distribution of RHS mutations shows regional specificities.

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Product Notes

The Human TAT tat (Catalog #AAA9325158) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325158 ELISA Kit recognizes Human TAT. It is sometimes possible for the material contained within the vial of "tyrosine aminotransferase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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