TRBP1 Blocking Peptide | TARBP1 blocking peptide

TRBP1 Peptide

Cat. Num. AAA152516

• Gene Names: TARBP1; TRM3; TRP185; TRP-185
• Applications: Blocking (BL)
• Synonyms: TRBP1; TRBP1 Peptide; TRM3; TRP185; TRP-185; Probable methyltransferase TARBP1; TAR RNA-binding protein 1; TAR (HIV-1) RNA binding protein 1; TARBP1 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 1621

• Applicable Applications for TARBP1 blocking peptide: Blocking (BL)
• Application Notes: TRBp1 peptide is used for blocking the activity of TRBP1 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 17 amino acid peptide from near the center of human TRBP1
• Preparation and Storage: Store TRBP1 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 110825988
• NCBI GeneID: 6894
• NCBI Accession #: NP_005637
• NCBI GenBank Nucleotide #: NM_005646.3
• UniProt Accession #: Q13395; Q9H581
• Molecular Weight: 181,675 Da
• NCBI Official Full Name: probable methyltransferase TARBP1
• NCBI Official Synonym Full Names: TAR (HIV-1) RNA binding protein 1
• NCBI Official Symbol: TARBP1
• NCBI Official Synonym Symbols: TRM3; TRP185; TRP-185
• NCBI Protein Information: probable methyltransferase TARBP1; TAR RNA-binding protein 1; TAR RNA loop binding protein; TAR (HIV) RNA binding protein 1; TAR (HIV) RNA-binding protein 1; tRNA methyltransferase 3 homolog; TAR RNA-binding protein of 185 kDa
• UniProt Protein Name: Probable methyltransferase TARBP1
• Protein Family: Probable methyltransferase
• UniProt Gene Name: TARBP1
• UniProt Synonym Gene Names: TRM3; TRP185; TRP-185
• UniProt Entry Name: TARB1_HUMAN

NCBI Description

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

TARBP1: Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA. Belongs to the RNA methyltransferase TrmH family.

Protein type: EC 2.1.1.-; RNA-binding; Methyltransferase

Chromosomal Location of Human Ortholog: 1q42.3

Cellular Component: nucleus

Molecular Function: RNA binding; RNA methyltransferase activity

Biological Process: regulation of transcription from RNA polymerase II promoter; RNA processing; RNA methylation