TATA box-binding protein-associated factor RNA polymerase I subunit A (TAF1A) Recombinant Protein | TAF1A recombinant protein

Recombinant Human TATA box-binding protein-associated factor RNA polymerase I subunit A (TAF1A)

Cat. Num. AAA1455579

• Gene Names: TAF1A; SL1; RAFI48; TAFI48; MGC:17061
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: TATA box-binding protein-associated factor RNA polymerase I subunit A (TAF1A); Recombinant Human TATA box-binding protein-associated factor RNA polymerase I subunit A (TAF1A); TAF1A recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-450, Full length protein
• Sequence: MSDFSEELKGPVTDDEEVETSVLSGAGMHFPWLQTYVETVAIGGKRRKDFAQTTSACLSFIQEALLKHQWQQAAEYMYSYFQTLEDSDSYKRQAAPEIIWKLGSEILFYHPKSNMESFNTFANRMKNIGVMNYLKISLQHALYLLHHGMLKDAKRNLSEAETWRHGENTSSREILINLIQAYKGLLQYYTWSEKKMELSKLDKDDYAYNAVAQDVFNHSWKTSANISALIKIPGVWDPFVKSYVEMLEFYGDRDGAQEVLTNYAYDEKFPSNPNAHIYLYNFLKRQKAPRSKLISVLKILYQIVPSHKLMLEFHTLLRKSEKEEHRKLGLEVLFGVLDFAGCTKNITAWKYLAKYLKNILMGNHLAWVQEEWNSRKNWWPGFHFSYFWAKSDWKEDTALACEKAFVAGLLLGKGCRYFRYILKQDHQILGKKIKRMKRSVKKYSIVNPRL
• Sequence Length: 450

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for TAF1A recombinant protein

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 319996599
• NCBI GeneID: 9015
• NCBI Accession #: NP_001188465.1
• NCBI GenBank Nucleotide #: NM_001201536.1
• UniProt Accession #: Q15573; Q9NWA1; B2RDZ8; D3DTB7
• Molecular Weight: 39,615 Da
• NCBI Official Full Name: TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1
• NCBI Official Synonym Full Names: TATA-box binding protein associated factor, RNA polymerase I subunit A
• NCBI Official Symbol: TAF1A
• NCBI Official Synonym Symbols: SL1; RAFI48; TAFI48; MGC:17061
• NCBI Protein Information: TATA box-binding protein-associated factor RNA polymerase I subunit A
• UniProt Protein Name: TATA box-binding protein-associated factor RNA polymerase I subunit A
• Protein Family: TATA box-binding protein-associated factor
• UniProt Gene Name: TAF1A
• UniProt Synonym Gene Names: TAFI48; TBP-associated factor 1A

NCBI Description

This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

Uniprot Description

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.