Canine Synaptophysin ELISA Kit | SYP elisa kit

Canine Synaptophysin ELISA Kit

Cat. Num. AAA11361

• Gene Names: SYP; MRXSYP
• Reactivity: Canine
• Synonyms: Synaptophysin; Canine Synaptophysin ELISA Kit; SYP elisa kit

• Reactivity: Canine

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 27764867
• NCBI GeneID: 6855
• NCBI Accession #: NP_003170.1
• NCBI GenBank Nucleotide #: NM_003179.2
• UniProt Accession #: P08247; Q6P2F7; B2R7L6
• Molecular Weight: 33,845 Da
• NCBI Official Full Name: synaptophysin
• NCBI Official Synonym Full Names: synaptophysin
• NCBI Official Symbol: SYP
• NCBI Official Synonym Symbols: MRXSYP
• NCBI Protein Information: synaptophysin; major synaptic vesicle protein P38
• UniProt Protein Name: Synaptophysin
• Protein Family: Synaptophysin
• UniProt Gene Name: SYP
• UniProt Entry Name: SYPH_HUMAN

NCBI Description

This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]

Uniprot Description

SYP: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Homohexamer or homotetramer. Interacts with SRCIN1. Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype. Belongs to the synaptophysin/synaptobrevin family.

Protein type: Membrane protein, multi-pass; Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp11.23-p11.22

Cellular Component: presynaptic membrane; synaptic vesicle; neuron projection; protein complex; synaptic vesicle membrane; presynaptic active zone; excitatory synapse; cell junction; integral to synaptic vesicle membrane

Molecular Function: identical protein binding; protein self-association; transporter activity; cholesterol binding; protein complex binding; syntaxin-1 binding; SH2 domain binding

Biological Process: regulation of long-term neuronal synaptic plasticity; synaptic vesicle maturation; synaptic vesicle membrane organization and biogenesis; endocytosis; regulation of short-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity

Disease: Mental Retardation, X-linked 96