Chemical Structure
(Chemical structure of VU0467154 (SIH-184), a M4 Receptor Agonist. CAS #: 1451993-15-9. Molecular Formula: C17H15F3N4O3S2. Molecular Weight: 444.45 g/mol.)
VU0467154 small molecule
VU0467154
Purity
0.9511
Synonyms
VU0467154; M4 Receptor Agonist; 5-amino-3; 4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2; 3-c]pyridazine-6-carboxamide; VU0467154 small molecule
Host
Synthetic
Purity/Purification
0.9511
Form/Format
Tan Solid
Solubility
Soluble in DMSO
CAS Number
1451993-15-9
Molecular Formula
C17H15F3N4O3S2
SMILES
O=S(C1=CC=C(C=C1)CNC(C2=C(N)C 3=C(C)C(C)=NN=C3S2)=O)(C(F)(F)F)= O
PubChem CID
PMC4324418
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of VU0467154 (SIH-184), a M4 Receptor Agonist. CAS #: 1451993-15-9. Molecular Formula: C17H15F3N4O3S2. Molecular Weight: 444.45 g/mol.)
Chemical Structure
(Chemical structure of VU0467154 (SIH-184), a M4 Receptor Agonist. CAS #: 1451993-15-9. Molecular Formula: C17H15F3N4O3S2. Molecular Weight: 444.45 g/mol.)
Related Product Information for VU0467154 small molecule
Allosteric activators of the M4 muscarinic acetylcholine receptor represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice.
Product Categories/Family for VU0467154 small molecule
References
1. Bubser M., et. al. (2014) ACS Clinical Neuroscience 5: 920 - 942.
Similar Products
Product Notes
The VU0467154 (Catalog #AAA807942) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "VU0467154, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
