STRA6 sirna

STRA6 siRNA (Rat)

Cat. Num. AAA8202203

• Gene Names: Stra6; RGD1307551
• Reactivity: Rat
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: STRA6; STRA6 siRNA (Rat); Stimulated by retinoic acid gene 6 protein homolog; STRA6 sirna

• Host: Synthetic
• Reactivity: Rat
• Specificity: STRA6 siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 670

• Applicable Applications for STRA6 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat STRA6 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for STRA6 sirna

siRNA to inhibit STRA6 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 71361637
• NCBI GeneID: 363071
• NCBI Accession #: NP_001025095.1
• NCBI GenBank Nucleotide #: NM_001029924.1
• UniProt Accession #: Q4QR83
• Molecular Weight: 73,763 Da
• NCBI Official Full Name: stimulated by retinoic acid gene 6 protein homolog
• NCBI Official Synonym Full Names: stimulated by retinoic acid 6
• NCBI Official Symbol: Stra6
• NCBI Official Synonym Symbols: RGD1307551
• NCBI Protein Information: stimulated by retinoic acid gene 6 protein homolog
• UniProt Protein Name: Stimulated by retinoic acid gene 6 protein homolog
• Protein Family: Stimulated by retinoic acid gene 6 protein
• UniProt Gene Name: Stra6
• UniProt Entry Name: STRA6_RAT

Uniprot Description

STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: protein complex; integral to membrane; plasma membrane

Molecular Function: receptor activity; vitamin transporter activity

Biological Process: blood vessel development; developmental growth; adrenal gland development; neuromuscular process; heart development; ear development; positive regulation of JAK-STAT cascade; digestive tract morphogenesis; vocal learning; learning; female genitalia development; nose morphogenesis; smooth muscle development; positive regulation of behavior; artery morphogenesis; retinoic acid metabolic process; feeding behavior; kidney development; cognition; alveolus development; embryonic gut development; lung development