TRK B Blocking Peptide | NTRK2 blocking peptide
TRK B Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.
Protein type: Protein kinase, TK; Membrane protein, integral; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 9q22.1
Cellular Component: cell surface; cytosol; dendritic spine; endosome membrane; growth cone; integral to plasma membrane; perikaryon; postsynaptic membrane; presynaptic active zone; receptor complex; rough endoplasmic reticulum; terminal button
Molecular Function: ATP binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity; receptor tyrosine kinase binding
Biological Process: adenylate cyclase activation; aging; brain-derived neurotrophic factor receptor signaling pathway; central nervous system neuron development; cerebral cortex development; circadian rhythm; feeding behavior; glutamate secretion; inflammatory response; learning; long-term memory; mechanoreceptor differentiation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; neuromuscular junction development; neuron differentiation; neuron migration; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system neuron development; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid autophosphorylation; regulation of dendrite development; regulation of GTPase activity; regulation of neurotransmitter secretion; regulation of protein kinase B signaling cascade; response to light stimulus; retina development in camera-type eye; retinal rod cell development; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis
Disease: Obesity, Hyperphagia, And Developmental Delay
Research Articles on NTRK2
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Product Notes
The NTRK2 ntrk2 (Catalog #AAA8243997) is a Blocking Peptide produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The TRK B Blocking Peptide reacts with Human, Mouse, Rat, Chicken, Monkey, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's TRK B can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours. Researchers should empirically determine the suitability of the NTRK2 ntrk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRK B, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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