SLC4A11 sirna

SLC4A11 siRNA (Mouse)

Cat. Num. AAA8224799

• Gene Names: Slc4a11; BTR1; NaBC1; AI503023
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: SLC4A11; SLC4A11 siRNA (Mouse); BTR1; Sodium bicarbonate transporter-like protein 11; Bicarbonate transporter-related protein 1; Sodium borate cotransporter 1; NaBC1; Solute carrier family 4 member 11; SLC4A11 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: SLC4A11 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 862

• Applicable Applications for SLC4A11 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse SLC4A11 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for SLC4A11 sirna

siRNA to inhibit SLC4A11 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 124487207
• NCBI GeneID: 269356
• NCBI Accession #: NP_001074631.1
• NCBI GenBank Nucleotide #: NM_001081162.1
• UniProt Accession #: A2AJN7; Q0VG86; Q3URQ1
• Molecular Weight: 96,751 Da
• NCBI Official Full Name: sodium bicarbonate transporter-like protein 11
• NCBI Official Synonym Full Names: solute carrier family 4, sodium bicarbonate transporter-like, member 11
• NCBI Official Symbol: Slc4a11
• NCBI Official Synonym Symbols: BTR1; NaBC1; AI503023
• NCBI Protein Information: sodium bicarbonate transporter-like protein 11
• UniProt Protein Name: Sodium bicarbonate transporter-like protein 11
• Protein Family: Sodium bicarbonate transporter-like protein
• UniProt Gene Name: Slc4a11
• UniProt Synonym Gene Names: BTR1; NaBC1
• UniProt Entry Name: S4A11_MOUSE

Uniprot Description

SLC4A11: Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD); also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive. Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2); also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive. Defects in SLC4A11 are the cause of corneal dystrophy Fuchs endothelial type 4 (FECD4); also known as Corneal dystrophy Fuchs endothelial late-onset. It is an ocular disorder caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. Belongs to the anion exchanger (TC 2.A.31) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: membrane; integral to plasma membrane; cell; integral to membrane; plasma membrane

Molecular Function: protein dimerization activity; bicarbonate transmembrane transporter activity; inorganic anion exchanger activity; transporter activity; symporter activity; anion:anion antiporter activity; boron transporter activity; anion transmembrane transporter activity; hydrogen ion channel activity; sodium channel activity

Biological Process: proton transport; fluid transport; cellular cation homeostasis; ion homeostasis; transport; inorganic anion transport; bicarbonate transport; sodium ion transport; regulation of intracellular pH; ion transport; anion transport; boron transport