ITGB1BP1 sirna

ITGB1BP1 siRNA (Mouse)

Cat. Num. AAA8200850

• Gene Names: Itgb1bp1; Icap1; AI449260; AU019480
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: ITGB1BP1; ITGB1BP1 siRNA (Mouse); Integrin beta-1-binding protein 1; Bodenin; ITGB1BP1 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: ITGB1BP1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 200

• Applicable Applications for ITGB1BP1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse ITGB1BP1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for ITGB1BP1 sirna

siRNA to inhibit ITGB1BP1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 6680488
• NCBI GeneID: 16413
• NCBI Accession #: NP_032429.1
• NCBI GenBank Nucleotide #: NM_008403.4
• UniProt Accession #: O35671; Q542A8
• Molecular Weight: 21,644 Da
• NCBI Official Full Name: integrin beta-1-binding protein 1
• NCBI Official Synonym Full Names: integrin beta 1 binding protein 1
• NCBI Official Symbol: Itgb1bp1
• NCBI Official Synonym Symbols: Icap1; AI449260; AU019480
• NCBI Protein Information: integrin beta-1-binding protein 1
• UniProt Protein Name: Integrin beta-1-binding protein 1
• Protein Family: Integrin beta-1-binding protein
• UniProt Gene Name: Itgb1bp1
• UniProt Entry Name: ITBP1_MOUSE

Uniprot Description

ICAP1: May play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion. Isoform 2 does not bind the integrin cytoplasmic domain-associated protein-1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion

Cellular Component: ruffle; cell projection; cytoskeleton; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: integrin binding; protein C-terminus binding; protein binding; GDP-dissociation inhibitor activity; protein complex binding; protein kinase binding; kinase binding; protein transporter activity

Biological Process: integrin activation; cell-matrix adhesion; receptor clustering; negative regulation of cell proliferation; protein transport; regulation of cell adhesion mediated by integrin; positive regulation of focal adhesion formation; regulation of transcription, DNA-dependent; biomineral formation; positive regulation of stress fiber formation; positive regulation of cell proliferation; angiogenesis; cell adhesion; cell differentiation; regulation of blood vessel size; negative regulation of protein binding; positive regulation of Notch signaling pathway; regulation of cell adhesion; integrin-mediated signaling pathway; substrate-bound cell migration, cell release from substrate; Notch signaling pathway; transcription, DNA-dependent; activation of protein kinase B; negative regulation of focal adhesion formation; lumen formation; positive regulation of protein kinase B signaling cascade; blood vessel endothelial cell proliferation during sprouting angiogenesis; positive regulation of cell division; myoblast migration; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter