ADIPOR1 sirna

ADIPOR1 siRNA (Mouse)

Cat. Num. AAA827052

• Gene Names: Adipor1; Paqr1; ACDCR1; CGI-45; 2810031L11Rik
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: ADIPOR1; ADIPOR1 siRNA (Mouse); Adiponectin receptor protein 1; ADIPOR1 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: ADIPOR1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 375

• Applicable Applications for ADIPOR1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse ADIPOR1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for ADIPOR1 sirna

siRNA to inhibit ADIPOR1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 807045897
• NCBI GeneID: 72674
• NCBI Accession #: NP_001292998.1
• NCBI GenBank Nucleotide #: NM_001306069.1
• UniProt Accession #: Q91VH1; Q9CZA0
• Molecular Weight: 42,366 Da
• NCBI Official Full Name: adiponectin receptor protein 1
• NCBI Official Synonym Full Names: adiponectin receptor 1
• NCBI Official Symbol: Adipor1
• NCBI Official Synonym Symbols: Paqr1; ACDCR1; CGI-45; 2810031L11Rik
• NCBI Protein Information: adiponectin receptor protein 1
• UniProt Protein Name: Adiponectin receptor protein 1
• Protein Family: Adiponectin receptor protein
• UniProt Gene Name: Adipor1
• UniProt Entry Name: ADR1_MOUSE

NCBI Description

This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Description

ADIPOR1: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. Belongs to the ADIPOR family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: adiponectin binding; identical protein binding; protein binding; hormone binding; protein heterodimerization activity; receptor activity; protein kinase binding

Biological Process: hormone-mediated signaling; positive regulation of JAK-STAT cascade; adiponectin-mediated signaling pathway; fatty acid oxidation; negative regulation of cell growth; lipid metabolic process; positive regulation of insulin receptor signaling pathway; fatty acid metabolic process; leptin-mediated signaling pathway