Goat KLHDC8B Polyclonal Antibody | anti-KLHDC8B antibody

Goat anti-KLHDC8B Antibody

Cat. Num. AAA422620

• Gene Names: KLHDC8B; CHL
• Reactivity: Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
• Applications: ELISA, Western Blot
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: KLHDC8B; Polyclonal Antibody; Goat anti-KLHDC8B Antibody; kelch domain containing 8B; FLJ11302; MGC35097; kelch domain-containing protein 8B; FLJ11302 antibody; kelch domain containing 8B antibody; kelch domain-containing protein 8B antibody; MGC35097 antibody; KLHDC8B antibody; anti-KLHDC8B antibody

• Host: Goat
• Reactivity: Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: 100ug specific antibody in 200ul (varies by lot)
• Sequence: TKLPRSLRMRDK
• Sequence Length: 354

• Applicable Applications for anti-KLHDC8B antibody: Peptide ELISA (EIA), Western Blot (WB)
• Application Notes: Peptide ELISA: Antibody detection limit dilution 1: 64000.
• Immunogen: Peptide with sequence C-TKLPRSLRMRDK, from the internal region of the protein sequence according to NP_775817.1.
• Epitope: Internal region
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

Western Blot (WB)

((0.5ug/ml) staining of Daudi lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

NCBI and Uniprot Product Information

• NCBI GI #: 27734909
• NCBI GeneID: 200942
• NCBI Accession #: NP_775817.1
• NCBI GenBank Nucleotide #: NM_173546.2
• Molecular Weight: 37,676 Da
• NCBI Official Full Name: kelch domain-containing protein 8B
• NCBI Official Synonym Full Names: kelch domain containing 8B
• NCBI Official Symbol: KLHDC8B
• NCBI Official Synonym Symbols: CHL
• NCBI Protein Information: kelch domain-containing protein 8B
• UniProt Protein Name: Kelch domain-containing protein 8B
• Protein Family: Kelch domain-containing protein
• UniProt Gene Name: KLHDC8B
• UniProt Entry Name: KLD8B_HUMAN

NCBI Description

This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]

Uniprot Description

KLHDC8B: Defects in KLHDC8B are a cause of Hodgkin lymphoma (HL). A malignant disease characterized by progressive enlargement of the lymph nodes, spleen and general lymphoid tissue, and the presence of large, usually multinucleate, cells (Reed-Sternberg cells). Reed-Sternberg cells compose only 1-2% of the total tumor cell mass. The remainder is composed of a variety of reactive, mixed inflammatory cells consisting of lymphocytes, plasma cells, neutrophils, eosinophils and histiocytes. A chromosomal aberration disrupting KLHDC8B has been found in a family with the nodular sclerosis type of classic Hodgkin lymphoma. Translocation t(2,3)(q11.2;p21.31).

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cytoplasm

Disease: Leg, Absence Deformity Of, With Congenital Cataract