AIP-1 Blocking Peptide | MAGI2 blocking peptide

AIP-1 Blocking Peptide

Cat. Num. AAA8203954

• Gene Names: MAGI2; AIP1; AIP-1; ARIP1; SSCAM; MAGI-2; ACVRIP1
• Reactivity: Human
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: AIP-1; AIP-1 Blocking Peptide; ACVRINP1; AIP1; KIAA0705; Membrane-associated guanylate kinase; WW and PDZ domain-containing protein 2; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; Membrane-associated guanylate kinase inverted 2; MAGI-2; MAGI2 blocking peptide

• Host: Synthetic
• Reactivity: Human
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 1441

• Applicable Applications for MAGI2 blocking peptide: Blocking (BL)
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Directions for Use: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for MAGI2 blocking peptide

The peptide is used to block Anti-AIP-1 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 667477958
• NCBI GeneID: 9863
• NCBI Accession #: NP_001288057.1
• NCBI GenBank Nucleotide #: NM_001301128.1
• UniProt Accession #: Q86UL8; O60434; O60510; Q86UI7; Q9NP44; Q9UDQ5; Q9UDU1; A4D1C1; A7E2C3
• Molecular Weight: 157,236 Da
• NCBI Official Full Name: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 2
• NCBI Official Synonym Full Names: membrane associated guanylate kinase, WW and PDZ domain containing 2
• NCBI Official Symbol: MAGI2
• NCBI Official Synonym Symbols: AIP1; AIP-1; ARIP1; SSCAM; MAGI-2; ACVRIP1
• NCBI Protein Information: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
• UniProt Protein Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
• Protein Family: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein
• UniProt Gene Name: MAGI2
• UniProt Synonym Gene Names: ACVRINP1; AIP1; KIAA0705; AIP-1; MAGI-2
• UniProt Entry Name: MAGI2_HUMAN

NCBI Description

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]

Uniprot Description

AIP1: a scaffold molecule at synaptic junctions that apparently couples neurotransmitter receptors and cell adhesion proteins. Contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. Contains two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. This protein is brain specific, where it appears to be widely expressed in both neurons and glia. Enhances the ability of PTEN to suppress AKT1 activation. Two splice-variant isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q21

Cellular Component: tight junction; protein complex; perinuclear region of cytoplasm; late endosome; postsynaptic density; dendrite; cytoplasm; plasma membrane; synapse; nucleus

Molecular Function: signal transducer activity; protein binding; receptor signaling complex scaffold activity; beta-1 adrenergic receptor binding; SMAD binding; phosphatase binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; negative regulation of activin receptor signaling pathway; negative regulation of cell proliferation; negative regulation of protein kinase B signaling cascade; protein heterooligomerization; positive regulation of receptor internalization; negative regulation of cell migration; receptor clustering; cytoplasmic transport