RDH11 sirna

RDH11 siRNA (Human)

Cat. Num. AAA8200187

• Gene Names: RDH11; MDT1; CGI82; PSDR1; RALR1; SCALD; ARSDR1; HCBP12; RDJCSS; SDR7C1
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: RDH11; RDH11 siRNA (Human); ARSDR1; PSDR1; Retinol dehydrogenase 11; Androgen-regulated short-chain dehydrogenase/reductase 1; HCV core-binding protein HCBP12; Prostate short-chain dehydrogenase/reductase 1; Retinal reductase 1; RalR1; RDH11 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: RDH11 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 248

• Applicable Applications for RDH11 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human RDH11 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for RDH11 sirna

siRNA to inhibit RDH11 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 358001101
• NCBI GeneID: 51109
• NCBI Accession #: NP_001239579.1
• NCBI GenBank Nucleotide #: NM_001252650.1
• UniProt Accession #: Q8TC12; Q0QD40; Q6IAH5; Q9NRW0; Q9Y391; A6NDK3; A8K062; B2RB26; B4DDW0
• Molecular Weight: 27,402 Da
• NCBI Official Full Name: retinol dehydrogenase 11 isoform 2
• NCBI Official Synonym Full Names: retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
• NCBI Official Symbol: RDH11
• NCBI Official Synonym Symbols: MDT1; CGI82; PSDR1; RALR1; SCALD; ARSDR1; HCBP12; RDJCSS; SDR7C1
• NCBI Protein Information: retinol dehydrogenase 11
• UniProt Protein Name: Retinol dehydrogenase 11
• Protein Family: Retinol dehydrogenase
• UniProt Gene Name: RDH11
• UniProt Synonym Gene Names: ARSDR1; PSDR1; SDR7C1; RalR1
• UniProt Entry Name: RDH11_HUMAN

NCBI Description

The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]

Uniprot Description

RDH11: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Oxidoreductase; EC 1.1.1.300; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: endoplasmic reticulum membrane; photoreceptor inner segment; integral to membrane; intracellular

Molecular Function: retinol dehydrogenase activity

Biological Process: phototransduction, visible light; retinal metabolic process; retinol metabolic process; adaptation of rhodopsin mediated signaling; retinoid metabolic process

Disease: Retinal Dystrophy, Juvenile Cataracts, And Short Stature Syndrome