NUP155 sirna

NUP155 siRNA (Human)

Cat. Num. AAA8238828

• Gene Names: NUP155; N155; ATFB15
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: NUP155; NUP155 siRNA (Human); KIAA0791; Nuclear pore complex protein Nup155; 155 kDa nucleoporin; Nucleoporin Nup155; NUP155 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: NUP155 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 1332

• Applicable Applications for NUP155 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human NUP155 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for NUP155 sirna

siRNA to inhibit NUP155 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 4758844
• NCBI GeneID: 9631
• NCBI Accession #: NP_004289.1
• NCBI GenBank Nucleotide #: NM_004298.3
• UniProt Accession #: O75694; Q9UBE9; Q9UFL5
• Molecular Weight: 149,016 Da
• NCBI Official Full Name: nuclear pore complex protein Nup155 isoform 2
• NCBI Official Synonym Full Names: nucleoporin 155kDa
• NCBI Official Symbol: NUP155
• NCBI Official Synonym Symbols: N155; ATFB15
• NCBI Protein Information: nuclear pore complex protein Nup155
• UniProt Protein Name: Nuclear pore complex protein Nup155
• Protein Family: Nuclear pore complex protein
• UniProt Gene Name: NUP155
• UniProt Synonym Gene Names: KIAA0791
• UniProt Entry Name: NU155_HUMAN

NCBI Description

Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

Uniprot Description

NUP155: Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Belongs to the non-repetitive/WGA-negative nucleoporin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleoporin

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: nuclear membrane; membrane; nuclear pore; nuclear envelope

Molecular Function: structural constituent of nuclear pore; transporter activity

Biological Process: viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; viral infectious cycle; glucose transport; nuclear membrane organization and biogenesis; mRNA export from nucleus; protein import into nucleus; hexose transport; carbohydrate metabolic process; viral transcription; gene expression; mitotic cell cycle; transmembrane transport

Disease: Atrial Fibrillation, Familial, 15