Western Blot (WB)
(ALOXE3 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ALOXE3 antibody detected the ALOXE3 protein (arrow).)
Rabbit anti-Human, mouse ALOXE3 Polyclonal Antibody | anti-ALOXE3 antibody
ALOXE3 Antibody (Center)
Western Blot (WB)
(ALOXE3 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ALOXE3 antibody detected the ALOXE3 protein (arrow).)
Western Blot (WB)
(ALOXE3 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ALOXE3 antibody detected the ALOXE3 protein (arrow).)
are catabolized by arachidonic acid-derived compounds. The encoded
enzyme is a hydroperoxide isomerase that synthesizes a unique type
of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic
acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This
epoxy alcohol can activate the the nuclear receptor peroxisome
proliferator-activated receptor alpha (PPARalpha), which is
implicated in epidermal differentiation. Loss of function of the
enzyme encoded by this gene results in ichthyosis, implicating the
function of this gene in the differentiation of human skin.
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Vahlquist, A., et al. J. Invest. Dermatol. 130(2):438-443(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)
Yu, Z., et al. Lipids 42(6):491-497(2007)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Description
ALOXE3: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known. Defects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non- bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Belongs to the lipoxygenase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 4.2.1.152; EC 5.4.4.7; Oxidoreductase
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytoplasm
Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; hepoxilin A3 synthase activity; protein binding; iron ion binding; lyase activity
Biological Process: fat cell differentiation; sphingolipid metabolic process; lipoxygenase pathway; ceramide biosynthetic process; arachidonic acid metabolic process; linoleic acid metabolic process; hepoxilin biosynthetic process; sensory perception of pain
Disease: Ichthyosis, Congenital, Autosomal Recessive 3; Ichthyosis, Congenital, Autosomal Recessive 2
Research Articles on ALOXE3
Similar Products
Product Notes
The ALOXE3 aloxe3 (Catalog #AAA9213076) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 223-252. The ALOXE3 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ALOXE3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ALOXE3 aloxe3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ALOXE3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
