KANK2 sirna

KANK2 siRNA (Human)

Cat. Num. AAA8207571

• Gene Names: KANK2; SIP; MXRA3; PPKWH; ANKRD25
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: KANK2; KANK2 siRNA (Human); ANKRD25; KIAA1518; MXRA3; SIP; KN motif and ankyrin repeat domain-containing protein 2; Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein; SRC-interacting protein; SRC1-interacting protein; KANK2 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: KANK2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 841

• Applicable Applications for KANK2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human KANK2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for KANK2 sirna

siRNA to inhibit KANK2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 209969812
• NCBI GeneID: 25959
• NCBI Accession #: NP_001129663.1
• NCBI GenBank Nucleotide #: NM_001136191.2
• UniProt Accession #: Q63ZY3; Q3KQZ3; Q6GUF5; Q9H8S4; Q9NUP0; Q9P210; B0I1P4
• Molecular Weight: 90,044 Da
• NCBI Official Full Name: KN motif and ankyrin repeat domain-containing protein 2 isoform 2
• NCBI Official Synonym Full Names: KN motif and ankyrin repeat domains 2
• NCBI Official Symbol: KANK2
• NCBI Official Synonym Symbols: SIP; MXRA3; PPKWH; ANKRD25
• NCBI Protein Information: KN motif and ankyrin repeat domain-containing protein 2
• UniProt Protein Name: KN motif and ankyrin repeat domain-containing protein 2
• Protein Family: KN motif and ankyrin repeat domain-containing protein
• UniProt Gene Name: KANK2
• UniProt Synonym Gene Names: ANKRD25; KIAA1518; MXRA3; SIP; SIP; SRC-interacting protein; SRC1-interacting protein
• UniProt Entry Name: KANK2_HUMAN

Uniprot Description

ANKRD25: a mammalian growth regulatory protein containing five Ankyrin repeats, common protein-protein interaction motifs. Ankyrin repeats are found in proteins with diverse functions including transcriptional initiators, cell-cycle regulators, cytoskeletal, and ion transporters. Three alternatively spliced isoforms have been described.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: mitochondrion; cytoplasm

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; apoptosis; negative regulation of programmed cell death; negative regulation of transcription from RNA polymerase II promoter; negative regulation of estrogen receptor signaling pathway

Disease: Palmoplantar Keratoderma And Woolly Hair