ARMS2 sirna

ARMS2 siRNA (Human)

Cat. Num. AAA8203582

• Gene Names: ARMS2; ARMD8
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: ARMS2; ARMS2 siRNA (Human); Age-related maculopathy susceptibility protein 2; ARMS2 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: ARMS2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 107

• Applicable Applications for ARMS2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human ARMS2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for ARMS2 sirna

siRNA to inhibit ARMS2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 153792797
• NCBI GeneID: 387715
• NCBI Accession #: NP_001093137.1
• NCBI GenBank Nucleotide #: NM_001099667.1
• UniProt Accession #: P0C7Q2; B2Y7I5
• Molecular Weight: 11,437 Da
• NCBI Official Full Name: age-related maculopathy susceptibility protein 2
• NCBI Official Synonym Full Names: age-related maculopathy susceptibility 2
• NCBI Official Symbol: ARMS2
• NCBI Official Synonym Symbols: ARMD8
• NCBI Protein Information: age-related maculopathy susceptibility protein 2
• UniProt Protein Name: Age-related maculopathy susceptibility protein 2
• Protein Family: Age-related maculopathy susceptibility protein
• UniProt Gene Name: ARMS2
• UniProt Entry Name: ARMS2_HUMAN

NCBI Description

This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration. [provided by RefSeq, Oct 2008]

Uniprot Description

ARMS2: Defects in ARMS2 influence susceptibility to age-related macular degeneration type 8 (ARMD8). ARMD is the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch's membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific disease mechanisms that underlie the vast majority of cases are currently unknown. However, a number of studies have suggested that both genetic and environmental factors are likely to play a role.

Chromosomal Location of Human Ortholog: 10q26.13

Cellular Component: photoreceptor inner segment; mitochondrion

Biological Process: retinal homeostasis

Disease: Macular Degeneration, Age-related, 8