AMHR2 sirna

AMHR2 siRNA (Human)

Cat. Num. AAA829622

• Gene Names: AMHR2; AMHR; MRII; MISR2; MISRII
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: AMHR2; AMHR2 siRNA (Human); AMHR; MISR2; Anti-Muellerian hormone type-2 receptor; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII; AMHR2 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: AMHR2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 478

• Applicable Applications for AMHR2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human AMHR2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for AMHR2 sirna

siRNA to inhibit AMHR2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 257743467
• NCBI GeneID: 269
• NCBI Accession #: NP_001158162.1
• NCBI GenBank Nucleotide #: NM_001164690.1
• UniProt Accession #: Q16671; Q13762; Q647K2; A0AVE1; B9EGB7; E9PGD2; F8W1D2
• Molecular Weight: 51,827 Da
• NCBI Official Full Name: anti-Muellerian hormone type-2 receptor isoform 2
• NCBI Official Synonym Full Names: anti-Mullerian hormone receptor, type II
• NCBI Official Symbol: AMHR2
• NCBI Official Synonym Symbols: AMHR; MRII; MISR2; MISRII
• NCBI Protein Information: anti-Muellerian hormone type-2 receptor
• UniProt Protein Name: Anti-Muellerian hormone type-2 receptor
• Protein Family: Anti-Muellerian hormone type-2 receptor
• UniProt Gene Name: AMHR2
• UniProt Synonym Gene Names: AMHR; MISR2; AMH type II receptor; MISRII; MRII
• UniProt Entry Name: AMHR2_HUMAN

NCBI Description

This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]

Uniprot Description

MISR2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Protein kinase, TKL; Membrane protein, integral; EC 2.7.11.30; Kinase, protein; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; transforming growth factor beta receptor activity, type II; hormone binding; metal ion binding; receptor activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: Mullerian duct regression; transforming growth factor beta receptor signaling pathway; signal transduction; protein amino acid phosphorylation; sex differentiation

Disease: Persistent Mullerian Duct Syndrome, Types I And Ii