PIK3R6 blocking peptide

PIK3R6 Blocking Peptide

Cat. Num. AAA822460

• Gene Names: PIK3R6; C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP)
• Reactivity: Human, Mouse, Rat
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: PIK3R6; PIK3R6 Blocking Peptide; C17orf38; Phosphoinositide 3-kinase regulatory subunit 6; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; p84 PI3K adapter protein; p84 PIKAP; p87 PI3K adapter protein; p87PIKAP; PIK3R6 blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse, Rat
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 754

• Applicable Applications for PIK3R6 blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for PIK3R6 blocking peptide

The peptide is used to block Anti-PIK3R6 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 58082081
• NCBI GeneID: 146850
• NCBI Accession #: NP_001010855.1
• NCBI GenBank Nucleotide #: NM_001010855.3
• UniProt Accession #: Q5UE93; Q658R3
• Molecular Weight: 84,258 Da
• NCBI Official Full Name: phosphoinositide 3-kinase regulatory subunit 6 isoform 1
• NCBI Official Synonym Full Names: phosphoinositide-3-kinase, regulatory subunit 6
• NCBI Official Symbol: PIK3R6
• NCBI Official Synonym Symbols: C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP)
• NCBI Protein Information: phosphoinositide 3-kinase regulatory subunit 6; p84 PI3K adapter protein; PI3Kgamma adapter protein of 87 kDa; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
• UniProt Protein Name: Phosphoinositide 3-kinase regulatory subunit 6
• Protein Family: Phosphoinositide 3-kinase regulatory
• UniProt Gene Name: PIK3R6
• UniProt Synonym Gene Names: C17orf38; p84 PIKAP; p87PIKAP
• UniProt Entry Name: PI3R6_HUMAN

NCBI Description

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Description

PIK3R6: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS1 bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane; cytosol

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity

Biological Process: positive regulation of MAP kinase activity; platelet activation; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; angiogenesis; blood coagulation; regulation of phosphoinositide 3-kinase activity