PDE4B/C/D Blocking Peptide | PDE4B blocking peptide

PDE4B/C/D Blocking Peptide

Cat. Num. AAA822606

• Gene Names: PDE4B; DPDE4; PDEIVB
• Reactivity: Human
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: PDE4B/C/D; PDE4B/C/D Blocking Peptide; PDE4B; DPDE4; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4B; PDE32; PDE4C; DPDE1; 5'-cyclic phosphodiesterase 4C; PDE21; PDE4D; DPDE3; 5'-cyclic phosphodiesterase 4D; PDE43; PDE4B blocking peptide

• Host: Synthetic
• Reactivity: Human
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 564

• Applicable Applications for PDE4B blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for PDE4B blocking peptide

The peptide is used to block Anti-PDE4B/C/D Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 82799482
• NCBI GeneID: 5142
• NCBI Accession #: NP_001032416.1
• NCBI GenBank Nucleotide #: NM_001037339.2
• UniProt Accession #: Q07343; O15443; Q13945; Q5TEK4; Q5TEK5; Q5TEK6; A5YW33
• Molecular Weight: 57,709 Da
• NCBI Official Full Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 2
• NCBI Official Synonym Full Names: phosphodiesterase 4B, cAMP-specific
• NCBI Official Symbol: PDE4B
• NCBI Official Synonym Symbols: DPDE4; PDEIVB
• NCBI Protein Information: cAMP-specific 3',5'-cyclic phosphodiesterase 4B; dunce-like phosphodiesterase E4; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
• UniProt Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
• Protein Family: cAMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE4B
• UniProt Synonym Gene Names: DPDE4
• UniProt Entry Name: PDE4B_HUMAN

NCBI Description

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Uniprot Description

PDE4B: a cAMP-specific phosphodiesterase. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. Inhibited by rolipram. Three alternatively-spliced isoforms have been described.

Protein type: Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.53

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: perinuclear region of cytoplasm; voltage-gated calcium channel complex; nucleus; Z disc; cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding; cAMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity

Biological Process: neutrophil chemotaxis; positive regulation of interferon-gamma production; cAMP catabolic process; positive regulation of interleukin-2 production; neutrophil homeostasis; T cell receptor signaling pathway; leukocyte migration