Western Blot (WB)
(Western Blot: Lane1: Porcine Brain Tissue; Lane2: Porcine Stomach Tissue; Lane3: Porcine Heart Tissue.)
Rabbit anti-Human Purinergic Receptor P2X Polyclonal Antibody | anti-P2RX7 antibody
Polyclonal Antibody to Purinergic Receptor P2X, Ligand Gated Ion Channel 7 (P2RX7)
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Lane1: Porcine Brain Tissue; Lane2: Porcine Stomach Tissue; Lane3: Porcine Heart Tissue.)
Western Blot (WB)
(Western Blot: Lane1: Porcine Brain Tissue; Lane2: Porcine Stomach Tissue; Lane3: Porcine Heart Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant P2RX7, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant P2RX7, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Kidney Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Kidney Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Kidney Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Kidney Tissue))
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]
Uniprot Description
P2X7: a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: cell soma; cytoplasm; external side of plasma membrane; integral component of nuclear inner membrane; integral component of plasma membrane; intercellular junction; membrane; neuromuscular junction; plasma membrane; postsynapse; presynapse
Molecular Function: ATP binding; extracellularly ATP-gated cation channel activity; lipopolysaccharide binding; protein binding; protein homodimerization activity; purinergic nucleotide receptor activity; receptor binding
Biological Process: activation of MAPK activity; bleb formation; blood coagulation; cell morphogenesis; cell surface receptor signaling pathway; cellular response to dsRNA; cellular response to extracellular stimulus; ceramide biosynthetic process; collagen metabolic process; cytolysis; defense response to Gram-positive bacterium; excitatory postsynaptic potential; homeostasis of number of cells within a tissue; inflammatory response; membrane budding; membrane depolarization; membrane protein ectodomain proteolysis; mitochondrion organization; multicellular organismal protein catabolic process; NAD transport; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPKKK cascade; phagolysosome formation; phospholipid scrambling; phospholipid transfer to membrane; phospholipid translocation; pore complex assembly; positive regulation of bleb assembly; positive regulation of bone mineralization; positive regulation of calcium ion transport into cytosol; positive regulation of cytolysis; positive regulation of cytoskeleton organization; positive regulation of gamma-aminobutyric acid secretion; positive regulation of gene expression; positive regulation of glutamate secretion; positive regulation of glycolysis; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of ion transmembrane transport; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; positive regulation of T cell mediated cytotoxicity; protein amino acid phosphorylation; protein oligomerization; protein processing; reactive oxygen species metabolic process; regulation of killing of cells of other organism; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to drug; response to electrical stimulus; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal morphogenesis; synaptic vesicle exocytosis; T cell homeostasis; T cell proliferation
Disease: Leukemia, Chronic Lymphocytic
Research Articles on P2RX7
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Product Notes
The P2RX7 p2rx7 (Catalog #AAA2027681) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Purinergic Receptor P2X, Ligand Gated Ion Channel 7 (P2RX7) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Purinergic Receptor P2X can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 1-5ug/ml Immunocytochemistry in formalin fixed cells: 5-20ug/ml Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml Immunohistochemistry in paraffin section: 5-20ug/ml Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the P2RX7 p2rx7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Purinergic Receptor P2X, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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