CST complex subunit STN1 (OBFC1) Recombinant Protein | OBFC1 recombinant protein

Recombinant Macaca fascicularis CST complex subunit STN1 (OBFC1)

Cat. Num. AAA1358666

• Gene Names: STN1; OBFC1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: CST complex subunit STN1 (OBFC1); Recombinant Macaca fascicularis CST complex subunit STN1 (OBFC1); OBFC1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-368, Full length protein
• Sequence: MQPGSSRCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVPGVFLYNGHPIKQVDVLGTVVGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPSAARELSLTSQLKKLQETIERRTKIEIGDTIRVRGSIRTYREEREIHATAYYKVDDPVWNIQIARMLELPTIYRKIYDQPFRSSALEKEEALSNPGALDLPSLTSLLSEKAKEFLMENRVQSFYQQELEMVESLLCLANQPVIHSACSDQVNFKKDTTSKAIHSIFKNAIQLLREKGLVFQKDDGFDNLYYVTREDKDLHRKIHQIIQQDCQKPNHMEKGCHFLHILACARLSIRPGLSEAVLQQVLELLEDQSDIVSTMEHYYTAF
• Sequence Length: 368

• Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 548961287
• NCBI GeneID: 101866940
• NCBI Accession #: NP_001271808.1
• NCBI GenBank Nucleotide #: NM_001284879.1
• UniProt Accession #: Q4R804
• Molecular Weight: 42,196 Da
• NCBI Official Full Name: CST complex subunit STN1
• NCBI Official Symbol: STN1
• NCBI Official Synonym Symbols: OBFC1
• NCBI Protein Information: CST complex subunit STN1
• UniProt Protein Name: CST complex subunit STN1
• Protein Family: CST complex
• UniProt Gene Name: STN1

Uniprot Description

Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication ().