STC2 recombinant protein

STC2 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8121494

• Gene Names: STC2; STC-2; STCRP
• Purity: >85% as determined by SDS-PAGE
• Synonyms: STC2; STC2 Protein; Human; Recombinant (hFc Tag); Human STC2/Stanniocalcin 2 Protein (Fc Tag); STC-2 Protein; STCRP Protein; stanniocalcin 2; STC2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >85% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Arg302

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Thr 25
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human STC2 (O76061)(Met1-Arg302) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for STC2 recombinant protein

Background: STC2 is a secreted, homodimeric glycoprotein expressed in a wide variety of tissues. STC2 has an anti-hypocalcemic action on calcium and phosphate homeostasis. It may have autocrine or paracrine functions. Its C-terminus contains a cluster of histidine residues that may interact with metal ions. STC2 has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. It may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis.

References

Chang AC, et al. (1998) Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. Mol Cell Endocrinol. 141(1-2):95-9. Ishibashi K, et al. (1998) Molecular cloning of a second human stanniocalcin homologue (STC2). Biochem Biophys Res Commun. 250(2):252-8. uo CW, et al. (2005) Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Endocrinology. 146(1):469-76.

NCBI and Uniprot Product Information

• NCBI GI #: 4507267
• NCBI GeneID: 8614
• NCBI Accession #: NP_003705.1
• NCBI GenBank Nucleotide #: NM_003714.2
• UniProt Accession #: O76061
• Molecular Weight: 33,249 Da
• NCBI Official Full Name: stanniocalcin-2
• NCBI Official Synonym Full Names: stanniocalcin 2
• NCBI Official Symbol: STC2
• NCBI Official Synonym Symbols: STC-2; STCRP
• NCBI Protein Information: stanniocalcin-2; STC-related protein; stanniocalcin-related protein
• UniProt Protein Name: Stanniocalcin-2
• Protein Family: Stanniocalcin
• UniProt Gene Name: STC2
• UniProt Synonym Gene Names: STC-2; STC-related protein; STCRP
• UniProt Entry Name: STC2_HUMAN

NCBI Description

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]

Uniprot Description

STC2: a secreted protein that has an anti-hypocalcemic action on calcium and phosphate homeostasis. Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leucocytes.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum; perinuclear region of cytoplasm

Molecular Function: protein homodimerization activity; enzyme binding; hormone activity; heme binding

Biological Process: cellular calcium ion homeostasis; response to peptide hormone stimulus; response to vitamin D; negative regulation of multicellular organism growth; unfolded protein response; decidualization; response to oxidative stress; regulation of hormone biosynthetic process; embryo implantation