Proto-oncogene tyrosine-protein kinase Src (SRC) Recombinant Protein | SRC recombinant protein

Recombinant Chicken Proto-oncogene tyrosine-protein kinase Src (SRC), partial

• Gene Names: SRC; SDR; c-src; PP60C-SCR
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Proto-oncogene tyrosine-protein kinase Src (SRC); Recombinant Chicken Proto-oncogene tyrosine-protein kinase Src (SRC); partial; SRC recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 533

• Species: Chicken
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for SRC recombinant protein

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. This protein is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 311771630
• NCBI GeneID: 396442
• NCBI Accession #: NP_990788.2
• NCBI GenBank Nucleotide #: NM_205457.2
• UniProt Accession #: P00523; Q90992; Q90993; Q91343; Q91345; Q92013; Q98915
• Molecular Weight: 21,180 Da
• NCBI Official Full Name: proto-oncogene tyrosine-protein kinase Src
• NCBI Official Synonym Full Names: SRC proto-oncogene, non-receptor tyrosine kinase
• NCBI Official Symbol: SRC
• NCBI Official Synonym Symbols: SDR; c-src; PP60C-SCR
• NCBI Protein Information: proto-oncogene tyrosine-protein kinase Src
• UniProt Protein Name: Proto-oncogene tyrosine-protein kinase Src
• Protein Family: Proto-oncogene tyrosine-protein kinase
• UniProt Gene Name: SRC
• UniProt Synonym Gene Names: p60-Src

Uniprot Description

Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:1717492, PubMed:8550628). Involved in anchorage-independent cell growth (PubMed:19307596).