Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Spectrin beta chain, brain 3 (SPTBN4) Standard Curve.)
Human Spectrin beta Chain, Brain 3 (SPTBN4) ELISA Kit | SPTBN3 elisa kit
Human Spectrin beta Chain, Brain 3 (SPTBN4) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Spectrin beta chain, brain 3 (SPTBN4) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Spectrin beta chain, brain 3 (SPTBN4) Standard Curve.)
Background: Spectrin is an actin crosslinking and molecular scaffold protein that links the cell membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTbN4 is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. Abundantly expressed in brain and pancreatic islets.
NCBI and Uniprot Product Information
NCBI Description
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
SPTBN4: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: spectrin; axon hillock; PML body; adherens junction; nuclear matrix; membrane; cell soma; paranode region of axon; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; spectrin binding; structural constituent of cytoskeleton; phospholipid binding; ankyrin binding; actin binding; phosphatase binding
Biological Process: axon guidance; clustering of voltage-gated sodium channels; negative regulation of heart rate; actin filament capping; cytoskeletal anchoring; regulation of peptidyl-serine phosphorylation; central nervous system projection neuron axonogenesis; transmission of nerve impulse; regulation of sodium ion transport; positive regulation of multicellular organism growth; adult walking behavior; vesicle-mediated transport; fertilization; sensory perception of sound; axonogenesis
Research Articles on SPTBN3
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Product Notes
The Human SPTBN3 sptbn4 (Catalog #AAA9714017) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714017 ELISA Kit recognizes Human SPTBN3. It is sometimes possible for the material contained within the vial of "Spectrin beta Chain, Brain 3 (SPTBN4), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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