Human sperm associated antigen 9 ELISA Kit | SPAG9 elisa kit

Human C-Jun-amino-terminal kinase-interacting protein 4, SPAG9 ELISA Kit

Cat. Num. AAA9334122

• Gene Names: SPAG9; JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4
• Reactivity: Human
• Synonyms: sperm associated antigen 9; Human C-Jun-amino-terminal kinase-interacting protein 4; SPAG9 ELISA Kit; Human C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) ELISA kit; CT89; FLJ13450; FLJ14006; FLJ26141; FLJ34602; HLC4; JLP; KIAA0516; MGC117291; MGC14967; MGC74461; PHET; PIG6; HLC-4 protein; JNK interacting protein; JNK-associated leucine-zipper protein; JNK/SAPK-ass; SPAG9 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
• Assay Type: Sandwich
• Detection Range: 0.625 ng/ml - 20 ng/ml.
• Sensitivity: 0.1 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for SPAG9 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of SPAG9 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 194578921
• NCBI GeneID: 9043
• NCBI Accession #: NP_001123999.1
• NCBI GenBank Nucleotide #: NM_001130527.2
• UniProt Accession #: O60271; O60905; Q3KQU8; Q3MKM7; Q86WC7; Q86WC8; Q8IZX7; Q96II0; Q9H811; A6H8U5; A8MSX0; B4DHH2
• Molecular Weight: 146,205 Da
• NCBI Official Full Name: C-Jun-amino-terminal kinase-interacting protein 4 isoform 2
• NCBI Official Synonym Full Names: sperm associated antigen 9
• NCBI Official Symbol: SPAG9
• NCBI Official Synonym Symbols: JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4
• NCBI Protein Information: C-Jun-amino-terminal kinase-interacting protein 4; sunday driver 1; Max-binding protein; sperm surface protein; lung cancer oncogene 4; JNK interacting protein; cancer/testis antigen 89; JNK/SAPK-associated protein; proliferation-inducing gene 6; protein highly expressed in testis; human lung cancer oncogene 6 protein; sperm associated antigen 9 variant 5; mitogen-activated protein kinase 8-interacting protein 4; c-Jun NH2-terminal kinase-associated leucine zipper protein
• UniProt Protein Name: C-Jun-amino-terminal kinase-interacting protein 4
• Protein Family: C-Jun-amino-terminal kinase-interacting protein
• UniProt Gene Name: SPAG9
• UniProt Synonym Gene Names: HSS; KIAA0516; MAPK8IP4; SYD1; HLC6; JIP-4; JNK-interacting protein 4; CT89; HLC-6; JLP; PHET
• UniProt Entry Name: JIP4_HUMAN

NCBI Description

This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Uniprot Description

JIP4: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction. Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1. Isoform 3 is increased in systemic sclerosis fibroblasts. Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. Belongs to the JIP scaffold family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: perinuclear region of cytoplasm; cytoplasm; acrosome; integral to membrane; cytosol

Molecular Function: JUN kinase binding; protein binding; MAP-kinase scaffold activity; mitogen-activated protein kinase p38 binding; receptor signaling complex scaffold activity; kinesin binding

Biological Process: muscle cell differentiation; positive regulation of muscle cell differentiation; striated muscle cell differentiation; spermatogenesis; positive regulation of neuron differentiation; retrograde transport, endosome to Golgi; activation of JNK activity; protein homooligomerization; positive regulation of cell migration