Human C-Jun-amino-terminal kinase-interacting protein 4 ELISA Kit | SPAG9 elisa kit

Human C-Jun-amino-terminal kinase-interacting protein 4 ELISA Kit

Cat. Num. AAA2883469

• Gene Names: SPAG9; JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4
• Reactivity: Human
• Synonyms: C-Jun-amino-terminal kinase-interacting protein 4; Human C-Jun-amino-terminal kinase-interacting protein 4 ELISA Kit; JIP-4; JNK-interacting protein 4; Cancer/testis antigen 89; CT89; Human lung cancer oncogene 6 protein; HLC-6; SPAG9 elisa kit

• Reactivity: Human
• Sequence Length: 1311

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/ml
• Sensitivity: 0.056ng/ml
• Intra-Assay CV: <=5.1%
• Inter-Assay CV: <=10.2%
• Recovery: 87%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 194578921
• NCBI GeneID: 9043
• NCBI Accession #: NP_001123999.1
• NCBI GenBank Nucleotide #: NM_001130527.2
• UniProt Accession #: O60271; O60905; Q3KQU8; Q3MKM7; Q86WC7; Q86WC8; Q8IZX7; Q96II0; Q9H811; A6H8U5; A8MSX0; B4DHH2
• Molecular Weight: 128,607 Da
• NCBI Official Full Name: C-Jun-amino-terminal kinase-interacting protein 4 isoform 2
• NCBI Official Synonym Full Names: sperm associated antigen 9
• NCBI Official Symbol: SPAG9
• NCBI Official Synonym Symbols: JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4
• NCBI Protein Information: C-Jun-amino-terminal kinase-interacting protein 4
• UniProt Protein Name: C-Jun-amino-terminal kinase-interacting protein 4
• Protein Family: C-Jun-amino-terminal kinase-interacting protein
• UniProt Gene Name: SPAG9
• UniProt Synonym Gene Names: HSS; KIAA0516; MAPK8IP4; SYD1; JIP-4; JNK-interacting protein 4; CT89; HLC-6; JLP; PHET
• UniProt Entry Name: JIP4_HUMAN

NCBI Description

This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Uniprot Description

JIP4: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction. Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1. Isoform 3 is increased in systemic sclerosis fibroblasts. Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. Belongs to the JIP scaffold family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: acrosome; cytoplasm; cytosol; integral to membrane; microtubule organizing center; perinuclear region of cytoplasm

Molecular Function: JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; mitogen-activated protein kinase p38 binding; protein binding; receptor signaling complex scaffold activity

Biological Process: activation of JNK activity; muscle cell differentiation; positive regulation of cell migration; positive regulation of muscle cell differentiation; positive regulation of neuron differentiation; protein homooligomerization; retrograde transport, endosome to Golgi; spermatogenesis; striated muscle cell differentiation