Sperm-associated antigen 17 (SPAG17) Recombinant Protein | SPAG17 recombinant protein

Recombinant Human Sperm-associated antigen 17 (SPAG17) , partial

• Gene Names: SPAG17; PF6; CT143
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sperm-associated antigen 17 (SPAG17); Recombinant Human Sperm-associated antigen 17 (SPAG17); partial; SPAG17 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 2,223

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 46240864
• NCBI GeneID: 200162
• NCBI Accession #: NP_996879.1
• NCBI GenBank Nucleotide #: NM_206996.3
• UniProt Accession #: Q6Q759; Q8NAZ1; Q9NT21
• Molecular Weight: 251,742 Da
• NCBI Official Full Name: sperm-associated antigen 17
• NCBI Official Synonym Full Names: sperm associated antigen 17
• NCBI Official Symbol: SPAG17
• NCBI Official Synonym Symbols: PF6; CT143
• NCBI Protein Information: sperm-associated antigen 17
• UniProt Protein Name: Sperm-associated antigen 17
• Protein Family: Sperm-associated antigen
• UniProt Gene Name: SPAG17

NCBI Description

This gene encodes a central pair protein present in the axonemes of cells with a "9 + 2" organization of microtubules. The encoded protein is required for the proper function of the axoneme. Mutations in the orthologous gene in mice lead to primary ciliary dyskinesia characterized by immotile nasal and tracheal cilia, reduced clearance of nasal mucus, profound respiratory distress, hydrocephalus, and neonatal lethality within twelve hours of birth due to impaired airway mucociliary clearance. Single-nucleotide polymorphisms in this gene are associated with human height and targeted mutations lead to skeletal malformations affecting the limbs in mice, suggesting a role for this gene in skeletal development. [provided by RefSeq, Feb 2017]

Uniprot Description

Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts.