SP100 recombinant protein
Recombinant Human SP100
Immunological Tests: Standard ELISA test (checkerboard analysis of positive/negative sera panels); immunodot test.
Introduction: SP100 protein is Homodimer which takes part in the control of gene expression. SP100 interacts with members of the HP1 family of nonhistone chromosomal protein, such as CBX5 and CBX3 via the PxVxL motif and also interacts with Epstein-Barr virus EBNA-LP.The major isoform Sp100-A, has a calculated MW of 54 kDa, but exhibits aberrant electrophoretic mobilities, with an apparent MW OF 100 kDa.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
Uniprot Description
SP100: May play a role in the control of gene expression. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor; DNA-binding
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: nucleoplasm; PML body; Mre11 complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein domain specific binding; identical protein binding; protein binding; protein homodimerization activity; DNA binding; transcription coactivator activity; chromatin binding; transcription corepressor activity; kinase binding; transcription factor binding
Biological Process: retinoic acid receptor signaling pathway; response to retinoic acid; negative regulation of protein export from nucleus; transcription, DNA-dependent; viral reproduction; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; negative regulation of cell motility; negative regulation of transcription from RNA polymerase II promoter; regulation of angiogenesis; negative regulation of DNA binding; chromatin remodeling; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of viral transcription; response to cytokine stimulus; positive regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; telomere maintenance
Research Articles on SP100
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Product Notes
The SP100 sp100 (Catalog #AAA144807) is a Recombinant Protein produced from Sf9 Insect Cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SP100 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunodot. Western blot with PBC sera or monoclonal anti-hexa-His-tag antibody. Immunological Tests: Standard ELISA test (checkerboard analysis of positive/negative sera panels); immunodot test. Researchers should empirically determine the suitability of the SP100 sp100 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SP100, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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