Mouse Transcription factor SOX-9 ELISA Kit | Sox9 elisa kit

Mouse Transcription factor SOX-9 ELISA Kit

Cat. Num. AAA289267

• Gene Names: Sox9; AV220920; mKIAA4243; 2010306G03Rik
• Reactivity: Mouse
• Synonyms: Transcription factor SOX-9; Mouse Transcription factor SOX-9 ELISA Kit; Sox9; Sox-9; Sox9 elisa kit

• Reactivity: Mouse
• Sequence Length: 507

• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 165932321
• NCBI GeneID: 20682
• NCBI Accession #: NP_035578.3
• NCBI GenBank Nucleotide #: NM_011448.4
• UniProt Accession #: Q04887; Q8C7L2; Q91ZK2; Q99KQ0
• Molecular Weight: 56,077 Da
• NCBI Official Full Name: transcription factor SOX-9
• NCBI Official Synonym Full Names: SRY (sex determining region Y)-box 9
• NCBI Official Symbol: Sox9
• NCBI Official Synonym Symbols: AV220920; mKIAA4243; 2010306G03Rik
• NCBI Protein Information: transcription factor SOX-9
• UniProt Protein Name: Transcription factor SOX-9
• Protein Family: Transcription factor
• UniProt Gene Name: Sox9
• UniProt Synonym Gene Names: Sox-9
• UniProt Entry Name: SOX9_MOUSE

Uniprot Description

SOX9: Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Defects in SOX9 are the cause of campomelic dysplasia (CMD1). CMD1 is a rare, often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with male- to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage. Defects in SOX9 are the cause of 46,XX sex reversal type 2 (SRXX2). SRXX2 is a condition in which male gonads develop in a genetic female (female to male sex reversal).

Protein type: DNA-binding; Transcription factor

Cellular Component: nucleoplasm; nucleus; protein complex; transcription factor complex

Molecular Function: beta-catenin binding; bHLH transcription factor binding; chromatin binding; DNA binding; protein binding; protein heterodimerization activity; protein kinase activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity

Biological Process: astrocyte fate commitment; cAMP-mediated signaling; cartilage condensation; cartilage development; cell differentiation; cell fate commitment; cell fate specification; cell-cell adhesion; chondrocyte development; chromatin remodeling; cytoskeleton organization and biogenesis; endocrine pancreas development; epidermal growth factor receptor signaling pathway; epithelial to mesenchymal transition; extracellular matrix organization and biogenesis; hair follicle development; heart development; homeostasis of number of cells within a tissue; lacrimal gland development; male germ-line sex determination; male gonad development; male sex determination; negative regulation of apoptosis; negative regulation of bone mineralization; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of epithelial cell differentiation; negative regulation of epithelial cell proliferation; negative regulation of immune system process; negative regulation of myoblast differentiation; negative regulation of ossification; negative regulation of photoreceptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural crest cell development; Notch signaling pathway; nucleosome assembly; oligodendrocyte differentiation; otic vesicle formation; positive regulation of cell proliferation; positive regulation of chondrocyte differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein complex assembly; protein kinase B signaling cascade; regulation of cell adhesion; regulation of cell differentiation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; retina development in camera-type eye; Sertoli cell development; Sertoli cell differentiation; signal transduction; skeletal development; somatic stem cell maintenance; spermatogenesis; tissue homeostasis; transcription from RNA polymerase II promoter; transcription, DNA-dependent